Hypolaetin-7-O-β-D-xyloside from Juniperus communis fruits inhibits melanogenesis on zebrafish pigmentation

Eun Ju Jeong; Jonghwan Jegal; Ki Wung Chung; Sang Gyun Noh; Hae Young Chung; Youn Hee Nam; Tong Ho Kang; Su Nam Kim; Min Hye Yang

doi:10.1177/1934578x1701201107

Hypolaetin-7-O-β-D-xyloside from Juniperus communis fruits inhibits melanogenesis on zebrafish pigmentation

Eun Ju Jeong, Jonghwan Jegal, Ki Wung Chung, Sang Gyun Noh, Hae Young Chung, Youn Hee Nam, Tong Ho Kang, Su Nam Kim, Min Hye Yang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Hypolaetin-7-O-β-D-xyloside (1) is a naturally occurring flavonoid from Juniperus communis fruits. This study aimed to investigate anti-melanogenic effect of hypolaetin-7-O-β-D-xyloside on zebrafish pigmentation. The phenotype-based image analysis suggested that 1 suppressed the zebrafish pigmentation in a concentration-dependent manner (1-400 μM) as a reversible competitive inhibitor against the enzyme tyrosinase. According to the molecular docking simulation, the compound 1 interacted with residues His-263 of tyrosinase via hydrogen bonding. The present study provided direct experimental evidence for skin-lightening effect of 1 in an in vivo zebrafish model. Therapeutic attempts with the 1 might be useful in the management of skin pigmentation-related diseases.

Original language	English
Pages (from-to)	1687-1690
Number of pages	4
Journal	Natural Product Communications
Volume	12
Issue number	11
DOIs	https://doi.org/10.1177/1934578x1701201107
Publication status	Published - Nov 2017

Keywords

Anti-melanogenesis
Hypolaetin-7-O-β-D-xyloside
Molecular docking
Tyrosinase inhibitor
Zebrafish pigmentation

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10.1177/1934578x1701201107

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title = "Hypolaetin-7-O-β-D-xyloside from Juniperus communis fruits inhibits melanogenesis on zebrafish pigmentation",

abstract = "Hypolaetin-7-O-β-D-xyloside (1) is a naturally occurring flavonoid from Juniperus communis fruits. This study aimed to investigate anti-melanogenic effect of hypolaetin-7-O-β-D-xyloside on zebrafish pigmentation. The phenotype-based image analysis suggested that 1 suppressed the zebrafish pigmentation in a concentration-dependent manner (1-400 μM) as a reversible competitive inhibitor against the enzyme tyrosinase. According to the molecular docking simulation, the compound 1 interacted with residues His-263 of tyrosinase via hydrogen bonding. The present study provided direct experimental evidence for skin-lightening effect of 1 in an in vivo zebrafish model. Therapeutic attempts with the 1 might be useful in the management of skin pigmentation-related diseases.",

keywords = "Anti-melanogenesis, Hypolaetin-7-O-β-D-xyloside, Molecular docking, Tyrosinase inhibitor, Zebrafish pigmentation",

author = "Jeong, {Eun Ju} and Jonghwan Jegal and Chung, {Ki Wung} and Noh, {Sang Gyun} and Chung, {Hae Young} and Nam, {Youn Hee} and Kang, {Tong Ho} and Kim, {Su Nam} and Yang, {Min Hye}",

year = "2017",

month = nov,

doi = "10.1177/1934578x1701201107",

language = "English",

volume = "12",

pages = "1687--1690",

journal = "Natural Product Communications",

issn = "1934-578X",

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T1 - Hypolaetin-7-O-β-D-xyloside from Juniperus communis fruits inhibits melanogenesis on zebrafish pigmentation

AU - Jeong, Eun Ju

AU - Jegal, Jonghwan

AU - Chung, Ki Wung

AU - Noh, Sang Gyun

AU - Chung, Hae Young

AU - Nam, Youn Hee

AU - Kang, Tong Ho

AU - Kim, Su Nam

AU - Yang, Min Hye

PY - 2017/11

Y1 - 2017/11

N2 - Hypolaetin-7-O-β-D-xyloside (1) is a naturally occurring flavonoid from Juniperus communis fruits. This study aimed to investigate anti-melanogenic effect of hypolaetin-7-O-β-D-xyloside on zebrafish pigmentation. The phenotype-based image analysis suggested that 1 suppressed the zebrafish pigmentation in a concentration-dependent manner (1-400 μM) as a reversible competitive inhibitor against the enzyme tyrosinase. According to the molecular docking simulation, the compound 1 interacted with residues His-263 of tyrosinase via hydrogen bonding. The present study provided direct experimental evidence for skin-lightening effect of 1 in an in vivo zebrafish model. Therapeutic attempts with the 1 might be useful in the management of skin pigmentation-related diseases.

AB - Hypolaetin-7-O-β-D-xyloside (1) is a naturally occurring flavonoid from Juniperus communis fruits. This study aimed to investigate anti-melanogenic effect of hypolaetin-7-O-β-D-xyloside on zebrafish pigmentation. The phenotype-based image analysis suggested that 1 suppressed the zebrafish pigmentation in a concentration-dependent manner (1-400 μM) as a reversible competitive inhibitor against the enzyme tyrosinase. According to the molecular docking simulation, the compound 1 interacted with residues His-263 of tyrosinase via hydrogen bonding. The present study provided direct experimental evidence for skin-lightening effect of 1 in an in vivo zebrafish model. Therapeutic attempts with the 1 might be useful in the management of skin pigmentation-related diseases.

KW - Anti-melanogenesis

KW - Hypolaetin-7-O-β-D-xyloside

KW - Molecular docking

KW - Tyrosinase inhibitor

KW - Zebrafish pigmentation

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DO - 10.1177/1934578x1701201107

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VL - 12

SP - 1687

EP - 1690

JO - Natural Product Communications

JF - Natural Product Communications

IS - 11

ER -

Hypolaetin-7-O-β-D-xyloside from Juniperus communis fruits inhibits melanogenesis on zebrafish pigmentation

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Keywords

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