Identification of aberrant overexpression of long non-coding RNA MALAT1 and role as a regulatory microRNA in liver cancer

Woo Chan Shin; Jung Woo Eun; Qingyu Shen; Hyung Seok Kim; Hee Doo Yang; Sang Yean Kim; Young Min Ahn; Won Sang Park; Jung Young Lee; Suk Woo Nam

doi:10.1007/s13273-017-0048-z

Identification of aberrant overexpression of long non-coding RNA MALAT1 and role as a regulatory microRNA in liver cancer

Woo Chan Shin, Jung Woo Eun, Qingyu Shen, Hyung Seok Kim, Hee Doo Yang, Sang Yean Kim, Young Min Ahn, Won Sang Park, Jung Young Lee, Suk Woo Nam

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

MALAT1 is deregulated in various cancers. The underlying mechanisms of MALA T1-mediated tumorigenesis are unclear. We found that MALAT1 was highly overexpressed and its overexpression was significantly associated with poor prognosis of liver cancer patients analyzed from the TCGA Liver Hepatocellular Carcinoma and Gene Expression Omnibus databases of the National Center for Biotechnology Information. Microarray analysis to identify the miRNAs deregulated by silencing MALAT1 in two liver cancer cell lines, HepG2 and Hep3B, revealed the common deregulation of 16 miRNAs including miR-574 and miR-20b in both cell lines. The predicted targets of miR-574 and miR-20b were cancer-related pathways including the RAS, MAPK and Wnt/β-catenin pathways. Aberrant expression of MALAT1 might contribute to liver cancer tumorigenesis by deregulation of cancer-associated miRNAs.

Original language	English
Pages (from-to)	443-451
Number of pages	9
Journal	Molecular and Cellular Toxicology
Volume	13
Issue number	4
DOIs	https://doi.org/10.1007/s13273-017-0048-z
Publication status	Published - 1 Dec 2017

Bibliographical note

Publisher Copyright:
© 2017, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V., part of Springer Nature.

Keywords

Hepatocellular carcinoma
Long non-coding RNA
MALA T1
MicroRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13273-017-0048-z

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title = "Identification of aberrant overexpression of long non-coding RNA MALAT1 and role as a regulatory microRNA in liver cancer",

abstract = "MALAT1 is deregulated in various cancers. The underlying mechanisms of MALA T1-mediated tumorigenesis are unclear. We found that MALAT1 was highly overexpressed and its overexpression was significantly associated with poor prognosis of liver cancer patients analyzed from the TCGA Liver Hepatocellular Carcinoma and Gene Expression Omnibus databases of the National Center for Biotechnology Information. Microarray analysis to identify the miRNAs deregulated by silencing MALAT1 in two liver cancer cell lines, HepG2 and Hep3B, revealed the common deregulation of 16 miRNAs including miR-574 and miR-20b in both cell lines. The predicted targets of miR-574 and miR-20b were cancer-related pathways including the RAS, MAPK and Wnt/β-catenin pathways. Aberrant expression of MALAT1 might contribute to liver cancer tumorigenesis by deregulation of cancer-associated miRNAs.",

keywords = "Hepatocellular carcinoma, Long non-coding RNA, MALA T1, MicroRNA",

author = "Shin, {Woo Chan} and Eun, {Jung Woo} and Qingyu Shen and Kim, {Hyung Seok} and Yang, {Hee Doo} and Kim, {Sang Yean} and Ahn, {Young Min} and Park, {Won Sang} and Lee, {Jung Young} and Nam, {Suk Woo}",

note = "Publisher Copyright: {\textcopyright} 2017, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V., part of Springer Nature.",

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doi = "10.1007/s13273-017-0048-z",

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T1 - Identification of aberrant overexpression of long non-coding RNA MALAT1 and role as a regulatory microRNA in liver cancer

AU - Shin, Woo Chan

AU - Eun, Jung Woo

AU - Shen, Qingyu

AU - Kim, Hyung Seok

AU - Yang, Hee Doo

AU - Kim, Sang Yean

AU - Ahn, Young Min

AU - Park, Won Sang

AU - Lee, Jung Young

AU - Nam, Suk Woo

PY - 2017/12/1

Y1 - 2017/12/1

N2 - MALAT1 is deregulated in various cancers. The underlying mechanisms of MALA T1-mediated tumorigenesis are unclear. We found that MALAT1 was highly overexpressed and its overexpression was significantly associated with poor prognosis of liver cancer patients analyzed from the TCGA Liver Hepatocellular Carcinoma and Gene Expression Omnibus databases of the National Center for Biotechnology Information. Microarray analysis to identify the miRNAs deregulated by silencing MALAT1 in two liver cancer cell lines, HepG2 and Hep3B, revealed the common deregulation of 16 miRNAs including miR-574 and miR-20b in both cell lines. The predicted targets of miR-574 and miR-20b were cancer-related pathways including the RAS, MAPK and Wnt/β-catenin pathways. Aberrant expression of MALAT1 might contribute to liver cancer tumorigenesis by deregulation of cancer-associated miRNAs.

AB - MALAT1 is deregulated in various cancers. The underlying mechanisms of MALA T1-mediated tumorigenesis are unclear. We found that MALAT1 was highly overexpressed and its overexpression was significantly associated with poor prognosis of liver cancer patients analyzed from the TCGA Liver Hepatocellular Carcinoma and Gene Expression Omnibus databases of the National Center for Biotechnology Information. Microarray analysis to identify the miRNAs deregulated by silencing MALAT1 in two liver cancer cell lines, HepG2 and Hep3B, revealed the common deregulation of 16 miRNAs including miR-574 and miR-20b in both cell lines. The predicted targets of miR-574 and miR-20b were cancer-related pathways including the RAS, MAPK and Wnt/β-catenin pathways. Aberrant expression of MALAT1 might contribute to liver cancer tumorigenesis by deregulation of cancer-associated miRNAs.

KW - Hepatocellular carcinoma

KW - Long non-coding RNA

KW - MALA T1

KW - MicroRNA

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SN - 1738-642X

VL - 13

SP - 443

EP - 451

JO - Molecular and Cellular Toxicology

JF - Molecular and Cellular Toxicology

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ER -

Identification of aberrant overexpression of long non-coding RNA MALAT1 and role as a regulatory microRNA in liver cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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