Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*

S. M. Moon; H. Gu; H. J. Ryu; J. J. Kim; H. T. Kim; B. G. Han; K. Kimm; J. K. Lee; B. Oh

doi:10.1111/j.1399-0039.2005.00446.x

Identification of four novel HLA-DOA alleles, DOA010106, DOA0102, DOA0103, and DOA0104N, by sequence-based typing*

S. M. Moon, H. Gu, H. J. Ryu, J. J. Kim, H. T. Kim, B. G. Han, K. Kimm, J. K. Lee, B. Oh

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

DOA sequences are currently known to have identical protein sequences. However, in this study, we report four novel allele types of human leucocyte antigen-DOA, including one synonymous and three non-synonymous amino acid changes from the Korean population. DOA*010106 has identical protein sequence with previously known DOA*010103 except one nucleotide difference at codon 45 (TCG→TCA). In contrast, DOA*0102 and DOA*0103 have a sequence change at codon 99 (CTG→GTG) and codon 105 (CGC→TGC), causing non-synonymous amino acid changes, Leu99Val and Arg105Cys, respectively. In addition, DOA*0104N has a sequence deletion at codon 36 (CCC→CC-), resulting in a frame shift leading to a stop codon at codon 62.

Original language	English
Pages (from-to)	242-245
Number of pages	4
Journal	Tissue Antigens
Volume	66
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-0039.2005.00446.x
Publication status	Published - Sept 2005

Keywords

HLA-DOA*010106
HLA-DOA*0102
HLA-DOA*0103
HLA-DOA*0104N
Korean
New allele
Sequence-based typing

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10.1111/j.1399-0039.2005.00446.x

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title = "Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*",

abstract = "DOA sequences are currently known to have identical protein sequences. However, in this study, we report four novel allele types of human leucocyte antigen-DOA, including one synonymous and three non-synonymous amino acid changes from the Korean population. DOA*010106 has identical protein sequence with previously known DOA*010103 except one nucleotide difference at codon 45 (TCG→TCA). In contrast, DOA*0102 and DOA*0103 have a sequence change at codon 99 (CTG→GTG) and codon 105 (CGC→TGC), causing non-synonymous amino acid changes, Leu99Val and Arg105Cys, respectively. In addition, DOA*0104N has a sequence deletion at codon 36 (CCC→CC-), resulting in a frame shift leading to a stop codon at codon 62.",

keywords = "HLA-DOA*010106, HLA-DOA*0102, HLA-DOA*0103, HLA-DOA*0104N, Korean, New allele, Sequence-based typing",

author = "Moon, {S. M.} and H. Gu and Ryu, {H. J.} and Kim, {J. J.} and Kim, {H. T.} and Han, {B. G.} and K. Kimm and Lee, {J. K.} and B. Oh",

year = "2005",

month = sep,

doi = "10.1111/j.1399-0039.2005.00446.x",

language = "English",

volume = "66",

pages = "242--245",

journal = "Tissue Antigens",

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T1 - Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*

AU - Moon, S. M.

AU - Gu, H.

AU - Ryu, H. J.

AU - Kim, J. J.

AU - Kim, H. T.

AU - Han, B. G.

AU - Kimm, K.

AU - Lee, J. K.

AU - Oh, B.

PY - 2005/9

Y1 - 2005/9

N2 - DOA sequences are currently known to have identical protein sequences. However, in this study, we report four novel allele types of human leucocyte antigen-DOA, including one synonymous and three non-synonymous amino acid changes from the Korean population. DOA*010106 has identical protein sequence with previously known DOA*010103 except one nucleotide difference at codon 45 (TCG→TCA). In contrast, DOA*0102 and DOA*0103 have a sequence change at codon 99 (CTG→GTG) and codon 105 (CGC→TGC), causing non-synonymous amino acid changes, Leu99Val and Arg105Cys, respectively. In addition, DOA*0104N has a sequence deletion at codon 36 (CCC→CC-), resulting in a frame shift leading to a stop codon at codon 62.

AB - DOA sequences are currently known to have identical protein sequences. However, in this study, we report four novel allele types of human leucocyte antigen-DOA, including one synonymous and three non-synonymous amino acid changes from the Korean population. DOA*010106 has identical protein sequence with previously known DOA*010103 except one nucleotide difference at codon 45 (TCG→TCA). In contrast, DOA*0102 and DOA*0103 have a sequence change at codon 99 (CTG→GTG) and codon 105 (CGC→TGC), causing non-synonymous amino acid changes, Leu99Val and Arg105Cys, respectively. In addition, DOA*0104N has a sequence deletion at codon 36 (CCC→CC-), resulting in a frame shift leading to a stop codon at codon 62.

KW - HLA-DOA010106

KW - HLA-DOA0102

KW - HLA-DOA0103

KW - HLA-DOA0104N

KW - Korean

KW - New allele

KW - Sequence-based typing

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U2 - 10.1111/j.1399-0039.2005.00446.x

DO - 10.1111/j.1399-0039.2005.00446.x

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C2 - 16101837

AN - SCOPUS:24144485824

SN - 0001-2815

VL - 66

SP - 242

EP - 245

JO - Tissue Antigens

JF - Tissue Antigens

IS - 3

ER -

Identification of four novel HLA-DOA alleles, DOA010106, DOA0102, DOA0103, and DOA0104N, by sequence-based typing*

Abstract

Keywords

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