Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

Taelim Kim; Hye In Kim; Ji Young An; Jun Lee; Na Rae Lee; Jinyuk Heo; Ji Eun Kim; Jihyun Yu; Yong Sup Lee; Kyung Soo Inn; Nam Jung Kim

doi:10.1016/j.bmcl.2016.01.089

Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

Taelim Kim, Hye In Kim, Ji Young An, Jun Lee, Na Rae Lee, Jinyuk Heo, Ji Eun Kim, Jihyun Yu, Yong Sup Lee, Kyung Soo Inn, Nam Jung Kim

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In this study, a series of bis(4-hydroxy)benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells.

Original language	English
Pages (from-to)	1844-1848
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2016.01.089
Publication status	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Anti-cancer activities
Bisphenol
Complementary
Estrogen receptor (ER) agonists
Oxime ether

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2016.01.089

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Kim, T., Kim, H. I., An, J. Y., Lee, J., Lee, N. R., Heo, J., Kim, J. E., Yu, J., Lee, Y. S., Inn, K. S., & Kim, N. J. (2016). Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism. Bioorganic and Medicinal Chemistry Letters, 26(7), 1844-1848. https://doi.org/10.1016/j.bmcl.2016.01.089

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abstract = "In this study, a series of bis(4-hydroxy)benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells.",

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author = "Taelim Kim and Kim, {Hye In} and An, {Ji Young} and Jun Lee and Lee, {Na Rae} and Jinyuk Heo and Kim, {Ji Eun} and Jihyun Yu and Lee, {Yong Sup} and Inn, {Kyung Soo} and Kim, {Nam Jung}",

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doi = "10.1016/j.bmcl.2016.01.089",

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AU - Kim, Taelim

AU - Kim, Hye In

AU - An, Ji Young

AU - Lee, Jun

AU - Lee, Na Rae

AU - Heo, Jinyuk

AU - Kim, Ji Eun

AU - Yu, Jihyun

AU - Lee, Yong Sup

AU - Inn, Kyung Soo

AU - Kim, Nam Jung

PY - 2016

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KW - Anti-cancer activities

KW - Bisphenol

KW - Complementary

KW - Estrogen receptor (ER) agonists

KW - Oxime ether

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

Abstract

Bibliographical note

Keywords

UN SDGs

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