Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus

Young Min Son; Sung Min Ahn; Mi Seon Jang; Yang Soo Moon; Sang Hoon Kim; Kwang Keun Cho; Seung Hyun Han; Cheol Heui Yun

doi:10.1016/j.bbrc.2008.09.037

Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus

Young Min Son
, Sung Min Ahn
, Mi Seon Jang
, Yang Soo Moon
, Sang Hoon Kim
, Kwang Keun Cho
, Seung Hyun Han
, Cheol Heui Yun

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Resistin is an adipokine whose physiologic role in obesity, type II diabetes mellitus, and inflammatory diseases has been a subject of debate because while it is expressed in adipocytes and adipose tissue in mouse, it is expressed in leukocytes, such as macrophages, in human. In the present study, we attempt to define the effect of resistin on human dendritic cells (DCs) derived from CD14⁺ monocytes. When DCs were stimulated with lipoteichoic acid (LTA) and treated with various concentrations of resistin, antigen-uptake process and the endocytic capacity of DCs were decreased. It is intriguing that resistin attenuated cytokine production in LTA-primed DCs. Consequently, T cell activity was reduced when lymphocytes were mixed with Staphylococcus aureus-primed autologous DCs treated with resistin compared to S. aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs.

Original language	English
Pages (from-to)	599-604
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	376
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2008.09.037
Publication status	Published - 21 Nov 2008

Bibliographical note

Funding Information:
This work was supported by a grant of Biogreen 21 program (20080101-080-038-001-0200), Rural Development Administration and the Basic Research Program (R01-2006-000-10884-0) and the International Cooperation Program (K2071300001107B010001110), Korea Science & Engineering Foundation, Republic of Korea.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dendritic cells
Interferon-gamma
Interleukin-4
Lipoteichoic acid
Obesity
Resistin
Staphylococcus aureus
T cells

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10.1016/j.bbrc.2008.09.037

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title = "Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus",

abstract = "Resistin is an adipokine whose physiologic role in obesity, type II diabetes mellitus, and inflammatory diseases has been a subject of debate because while it is expressed in adipocytes and adipose tissue in mouse, it is expressed in leukocytes, such as macrophages, in human. In the present study, we attempt to define the effect of resistin on human dendritic cells (DCs) derived from CD14+ monocytes. When DCs were stimulated with lipoteichoic acid (LTA) and treated with various concentrations of resistin, antigen-uptake process and the endocytic capacity of DCs were decreased. It is intriguing that resistin attenuated cytokine production in LTA-primed DCs. Consequently, T cell activity was reduced when lymphocytes were mixed with Staphylococcus aureus-primed autologous DCs treated with resistin compared to S. aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs.",

keywords = "Dendritic cells, Interferon-gamma, Interleukin-4, Lipoteichoic acid, Obesity, Resistin, Staphylococcus aureus, T cells",

author = "Son, \{Young Min\} and Ahn, \{Sung Min\} and Jang, \{Mi Seon\} and Moon, \{Yang Soo\} and Kim, \{Sang Hoon\} and Cho, \{Kwang Keun\} and Han, \{Seung Hyun\} and Yun, \{Cheol Heui\}",

note = "Funding Information: This work was supported by a grant of Biogreen 21 program (20080101-080-038-001-0200), Rural Development Administration and the Basic Research Program (R01-2006-000-10884-0) and the International Cooperation Program (K2071300001107B010001110), Korea Science \& Engineering Foundation, Republic of Korea.",

year = "2008",

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doi = "10.1016/j.bbrc.2008.09.037",

language = "English",

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journal = "Biochemical and Biophysical Research Communications",

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TY - JOUR

T1 - Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus

AU - Son, Young Min

AU - Ahn, Sung Min

AU - Jang, Mi Seon

AU - Moon, Yang Soo

AU - Kim, Sang Hoon

AU - Cho, Kwang Keun

AU - Han, Seung Hyun

AU - Yun, Cheol Heui

N1 - Funding Information: This work was supported by a grant of Biogreen 21 program (20080101-080-038-001-0200), Rural Development Administration and the Basic Research Program (R01-2006-000-10884-0) and the International Cooperation Program (K2071300001107B010001110), Korea Science & Engineering Foundation, Republic of Korea.

PY - 2008/11/21

Y1 - 2008/11/21

N2 - Resistin is an adipokine whose physiologic role in obesity, type II diabetes mellitus, and inflammatory diseases has been a subject of debate because while it is expressed in adipocytes and adipose tissue in mouse, it is expressed in leukocytes, such as macrophages, in human. In the present study, we attempt to define the effect of resistin on human dendritic cells (DCs) derived from CD14+ monocytes. When DCs were stimulated with lipoteichoic acid (LTA) and treated with various concentrations of resistin, antigen-uptake process and the endocytic capacity of DCs were decreased. It is intriguing that resistin attenuated cytokine production in LTA-primed DCs. Consequently, T cell activity was reduced when lymphocytes were mixed with Staphylococcus aureus-primed autologous DCs treated with resistin compared to S. aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs.

AB - Resistin is an adipokine whose physiologic role in obesity, type II diabetes mellitus, and inflammatory diseases has been a subject of debate because while it is expressed in adipocytes and adipose tissue in mouse, it is expressed in leukocytes, such as macrophages, in human. In the present study, we attempt to define the effect of resistin on human dendritic cells (DCs) derived from CD14+ monocytes. When DCs were stimulated with lipoteichoic acid (LTA) and treated with various concentrations of resistin, antigen-uptake process and the endocytic capacity of DCs were decreased. It is intriguing that resistin attenuated cytokine production in LTA-primed DCs. Consequently, T cell activity was reduced when lymphocytes were mixed with Staphylococcus aureus-primed autologous DCs treated with resistin compared to S. aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs.

KW - Dendritic cells

KW - Interferon-gamma

KW - Interleukin-4

KW - Lipoteichoic acid

KW - Obesity

KW - Resistin

KW - Staphylococcus aureus

KW - T cells

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U2 - 10.1016/j.bbrc.2008.09.037

DO - 10.1016/j.bbrc.2008.09.037

M3 - Article

C2 - 18805395

AN - SCOPUS:53149117805

SN - 0006-291X

VL - 376

SP - 599

EP - 604

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus

Abstract

Bibliographical note

UN SDGs

Keywords

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