Induction of apoptosis by KI0477959 through activation of caspase-3 in human leukemia cell line, HL-60 cells

Hyun Ja Jeong; Ju Young Lee; Joon Bae Kim; Hoyeon Go; Seong Gyu Ko; Young Wan Seo; Sejin Jeong; Jinhan Park; Ho Jeong Na; Jae Young Um; Hyung Min Kim; Seung Heon Hong

doi:10.1080/00207450701242859

Induction of apoptosis by KI0477959 through activation of caspase-3 in human leukemia cell line, HL-60 cells

Hyun Ja Jeong
, Ju Young Lee
, Joon Bae Kim
, Hoyeon Go
, Seong Gyu Ko
, Young Wan Seo
, Sejin Jeong
, Jinhan Park
, Ho Jeong Na
, Jae Young Um
, Hyung Min Kim
, Seung Heon Hong

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

KI0477959 (Herbkines) has been used for the purpose of development of physical strength in wasting diseases, like cancer. In the present study, apoptosis-inducing activities of butanol fraction of KI0477959 were studied in human leukemia cell line, HL-60 cells. KI0477959 increased cytotoxicity but had less effect on human peripheral blood mononuclear cells. KI0477959-induced apoptosis was accompanied by activation of caspase-3 and specific proteolytic cleavage of poly-ADP-ribose polymerase. Increased apoptosis was reduced by treatment with p38 and extracellular signal-regulated protein kinase (ERK) inhibitors. These results suggest that KI0477959 induces apoptosis through activation of caspase-3, p38, and ERK in HL-60 cells.

Original language	English
Pages (from-to)	1384-1399
Number of pages	16
Journal	International Journal of Neuroscience
Volume	118
Issue number	10
DOIs	https://doi.org/10.1080/00207450701242859
Publication status	Published - Oct 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Butanol fraction of KI0477959
Caspase-3
Extracellular signal-regulated protein kinase
Human leukemia cells
p38

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10.1080/00207450701242859

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title = "Induction of apoptosis by KI0477959 through activation of caspase-3 in human leukemia cell line, HL-60 cells",

abstract = "KI0477959 (Herbkines) has been used for the purpose of development of physical strength in wasting diseases, like cancer. In the present study, apoptosis-inducing activities of butanol fraction of KI0477959 were studied in human leukemia cell line, HL-60 cells. KI0477959 increased cytotoxicity but had less effect on human peripheral blood mononuclear cells. KI0477959-induced apoptosis was accompanied by activation of caspase-3 and specific proteolytic cleavage of poly-ADP-ribose polymerase. Increased apoptosis was reduced by treatment with p38 and extracellular signal-regulated protein kinase (ERK) inhibitors. These results suggest that KI0477959 induces apoptosis through activation of caspase-3, p38, and ERK in HL-60 cells.",

keywords = "Apoptosis, Butanol fraction of KI0477959, Caspase-3, Extracellular signal-regulated protein kinase, Human leukemia cells, p38",

author = "Jeong, \{Hyun Ja\} and Lee, \{Ju Young\} and Kim, \{Joon Bae\} and Hoyeon Go and Ko, \{Seong Gyu\} and Seo, \{Young Wan\} and Sejin Jeong and Jinhan Park and Na, \{Ho Jeong\} and Um, \{Jae Young\} and Kim, \{Hyung Min\} and Hong, \{Seung Heon\}",

year = "2008",

month = oct,

doi = "10.1080/00207450701242859",

language = "English",

volume = "118",

pages = "1384--1399",

journal = "International Journal of Neuroscience",

issn = "0020-7454",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Induction of apoptosis by KI0477959 through activation of caspase-3 in human leukemia cell line, HL-60 cells

AU - Jeong, Hyun Ja

AU - Lee, Ju Young

AU - Kim, Joon Bae

AU - Go, Hoyeon

AU - Ko, Seong Gyu

AU - Seo, Young Wan

AU - Jeong, Sejin

AU - Park, Jinhan

AU - Na, Ho Jeong

AU - Um, Jae Young

AU - Kim, Hyung Min

AU - Hong, Seung Heon

PY - 2008/10

Y1 - 2008/10

N2 - KI0477959 (Herbkines) has been used for the purpose of development of physical strength in wasting diseases, like cancer. In the present study, apoptosis-inducing activities of butanol fraction of KI0477959 were studied in human leukemia cell line, HL-60 cells. KI0477959 increased cytotoxicity but had less effect on human peripheral blood mononuclear cells. KI0477959-induced apoptosis was accompanied by activation of caspase-3 and specific proteolytic cleavage of poly-ADP-ribose polymerase. Increased apoptosis was reduced by treatment with p38 and extracellular signal-regulated protein kinase (ERK) inhibitors. These results suggest that KI0477959 induces apoptosis through activation of caspase-3, p38, and ERK in HL-60 cells.

AB - KI0477959 (Herbkines) has been used for the purpose of development of physical strength in wasting diseases, like cancer. In the present study, apoptosis-inducing activities of butanol fraction of KI0477959 were studied in human leukemia cell line, HL-60 cells. KI0477959 increased cytotoxicity but had less effect on human peripheral blood mononuclear cells. KI0477959-induced apoptosis was accompanied by activation of caspase-3 and specific proteolytic cleavage of poly-ADP-ribose polymerase. Increased apoptosis was reduced by treatment with p38 and extracellular signal-regulated protein kinase (ERK) inhibitors. These results suggest that KI0477959 induces apoptosis through activation of caspase-3, p38, and ERK in HL-60 cells.

KW - Apoptosis

KW - Butanol fraction of KI0477959

KW - Caspase-3

KW - Extracellular signal-regulated protein kinase

KW - Human leukemia cells

KW - p38

UR - https://www.scopus.com/pages/publications/51849099496

U2 - 10.1080/00207450701242859

DO - 10.1080/00207450701242859

M3 - Article

C2 - 18788024

AN - SCOPUS:51849099496

SN - 0020-7454

VL - 118

SP - 1384

EP - 1399

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 10

ER -

Induction of apoptosis by KI0477959 through activation of caspase-3 in human leukemia cell line, HL-60 cells

Abstract

UN SDGs

Keywords

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