Abstract
Immunoglobulin E (IgE) is the principal immunoglobulin involved in immediate hypersensitivities and chronic allergic diseases. The effect of an aqueous extract of Poncirus trifoliata (L) Raf. (Rutaceae) fruits (PTFE) on in vivo and in vitro IgE production was investigated. PTFE dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin, Bordetella pertussis toxin and aluminum hydroxide gel. PTFE strongly inhibited interleukin 4 (IL-4)-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, PTFE also showed an inhibitory effect on the IgE production. These results suggest that PTFE has an anti-allergic activity by inhibition of IgE production from B cells. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 283-288 |
| Number of pages | 6 |
| Journal | Journal of Ethnopharmacology |
| Volume | 66 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sept 1999 |
Bibliographical note
Funding Information:This paper was supported by Non-directed Research Fund, Korea Research Foundation, 1996–1998 and partially by Wonkwang University in 1998.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- IgE
- Immunization
- Poncirus trifoliata
- Rutaceae
- U266 human IgE-bearing B cells
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