Inhibitory effect of anaphylactic reaction of Sosiho-Tang

H. M. Kim; Y. Y. Kim; H. S. Moon; E. H. Lee; S. J. Moon; N. H. An

doi:10.3109/08923979809031517

Inhibitory effect of anaphylactic reaction of Sosiho-Tang

H. M. Kim
, Y. Y. Kim
, H. S. Moon
, E. H. Lee
, S. J. Moon
, N. H. An

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity Fc receptor also stimulates the mast cells. The objective of the current study was to determine the effect of Sosiho- Tang (SS-Tang) on mast cell-mediated anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP IgE. These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation.

Original language	English
Pages (from-to)	567-578
Number of pages	12
Journal	Immunopharmacology and Immunotoxicology
Volume	20
Issue number	4
DOIs	https://doi.org/10.3109/08923979809031517
Publication status	Published - 1998

Bibliographical note

Funding Information:
This study is supported by the Oriental medicine fbnd of Ministry of Health

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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Cite this

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title = "Inhibitory effect of anaphylactic reaction of Sosiho-Tang",

abstract = "Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity Fc receptor also stimulates the mast cells. The objective of the current study was to determine the effect of Sosiho- Tang (SS-Tang) on mast cell-mediated anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP IgE. These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation.",

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AU - Kim, H. M.

AU - Kim, Y. Y.

AU - Moon, H. S.

AU - Lee, E. H.

AU - Moon, S. J.

AU - An, N. H.

PY - 1998

Y1 - 1998

N2 - Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity Fc receptor also stimulates the mast cells. The objective of the current study was to determine the effect of Sosiho- Tang (SS-Tang) on mast cell-mediated anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP IgE. These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation.

AB - Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity Fc receptor also stimulates the mast cells. The objective of the current study was to determine the effect of Sosiho- Tang (SS-Tang) on mast cell-mediated anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP IgE. These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation.

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DO - 10.3109/08923979809031517

M3 - Article

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SN - 0892-3973

VL - 20

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EP - 578

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 4

ER -

Inhibitory effect of anaphylactic reaction of Sosiho-Tang

Abstract

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