Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori

Jong Mi Kim; Ji Eun Shin; Myung Joo Han; Nam In Baek; Dong Hyun Kim

Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori

Jong Mi Kim
, Ji Eun Shin
, Myung Joo Han
, Nam In Baek
, Dong Hyun Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Polyacetylenes were isolated from Panax ginseng C.A. Meyer (Family Araliaceae), and their inhibitory effects on growth, infection and VacA vacuolation of Helicobacter pylori (BP) were investigated. Ginseng polyacetylenes did not inhibit the infection of HP into KATO cells. However, polyacetylenes inhibited HP growth and vacuolation of HeLa by VacA toxin. Panaxytriol showed the most potent inhibition with IC₅₀ values of 0.05 and 0.046 mg/ml, respectively.

Original language	English
Pages (from-to)	158-160
Number of pages	3
Journal	Natural Product Sciences
Volume	9
Issue number	3
Publication status	Published - Sept 2003

Keywords

Helicobacter pylori
Panax ginseng
Panaxytriol
Polyacetylenes
VacA toxin

Cite this

@article{2797d5b82e3945ba98abde8c9d781294,

title = "Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori",

abstract = "Polyacetylenes were isolated from Panax ginseng C.A. Meyer (Family Araliaceae), and their inhibitory effects on growth, infection and VacA vacuolation of Helicobacter pylori (BP) were investigated. Ginseng polyacetylenes did not inhibit the infection of HP into KATO cells. However, polyacetylenes inhibited HP growth and vacuolation of HeLa by VacA toxin. Panaxytriol showed the most potent inhibition with IC50 values of 0.05 and 0.046 mg/ml, respectively.",

keywords = "Helicobacter pylori, Panax ginseng, Panaxytriol, Polyacetylenes, VacA toxin",

author = "Kim, \{Jong Mi\} and Shin, \{Ji Eun\} and \{Joo Han\}, Myung and Baek, \{Nam In\} and Kim, \{Dong Hyun\}",

year = "2003",

month = sep,

language = "English",

volume = "9",

pages = "158--160",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "3",

}

TY - JOUR

T1 - Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori

AU - Kim, Jong Mi

AU - Shin, Ji Eun

AU - Joo Han, Myung

AU - Baek, Nam In

AU - Kim, Dong Hyun

PY - 2003/9

Y1 - 2003/9

N2 - Polyacetylenes were isolated from Panax ginseng C.A. Meyer (Family Araliaceae), and their inhibitory effects on growth, infection and VacA vacuolation of Helicobacter pylori (BP) were investigated. Ginseng polyacetylenes did not inhibit the infection of HP into KATO cells. However, polyacetylenes inhibited HP growth and vacuolation of HeLa by VacA toxin. Panaxytriol showed the most potent inhibition with IC50 values of 0.05 and 0.046 mg/ml, respectively.

AB - Polyacetylenes were isolated from Panax ginseng C.A. Meyer (Family Araliaceae), and their inhibitory effects on growth, infection and VacA vacuolation of Helicobacter pylori (BP) were investigated. Ginseng polyacetylenes did not inhibit the infection of HP into KATO cells. However, polyacetylenes inhibited HP growth and vacuolation of HeLa by VacA toxin. Panaxytriol showed the most potent inhibition with IC50 values of 0.05 and 0.046 mg/ml, respectively.

KW - Helicobacter pylori

KW - Panax ginseng

KW - Panaxytriol

KW - Polyacetylenes

KW - VacA toxin

UR - https://www.scopus.com/pages/publications/0141955218

M3 - Article

AN - SCOPUS:0141955218

SN - 1226-3907

VL - 9

SP - 158

EP - 160

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 3

ER -

Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori

Abstract

Keywords

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