Inhibitory effect of interleulin-1α-induced apoptosis by polygala tenuifolia in hep g2 cells

H. N. Koo; H. J. Jeong; K. R. Kim; J. C. Kim; K. S. Kim; B. K. Kang; H. M. Kim; J. J. Kim

doi:10.3109/08923970009026010

Inhibitory effect of interleulin-1α-induced apoptosis by polygala tenuifolia in hep g2 cells

H. N. Koo
, H. J. Jeong
, K. R. Kim
, J. C. Kim
, K. S. Kim
, B. K. Kang
, H. M. Kim
, J. J. Kim

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia WILLDENOW (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 υg/ml) dose- dependently inhibited the EtOH-induced interluekin-1 α (IL-1 α) secretion. PTAE (0.01-1 γg/ml) also inhibited the EtOH- and IL-1α-induced cytotoxicity. Furthermore, we found that PTAE inhibited the IL-1α-induced apoptosis of Hep G2 cells. These results suggest that PTAE may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells.

Original language	English
Pages (from-to)	531-544
Number of pages	14
Journal	Immunopharmacology and Immunotoxicology
Volume	22
Issue number	3
DOIs	https://doi.org/10.3109/08923970009026010
Publication status	Published - 2000

Access to Document

10.3109/08923970009026010

Cite this

@article{79ba711e31d24e8098b98653c7d4993d,

title = "Inhibitory effect of interleulin-1α-induced apoptosis by polygala tenuifolia in hep g2 cells",

abstract = "A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia WILLDENOW (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 υg/ml) dose- dependently inhibited the EtOH-induced interluekin-1 α (IL-1 α) secretion. PTAE (0.01-1 γg/ml) also inhibited the EtOH- and IL-1α-induced cytotoxicity. Furthermore, we found that PTAE inhibited the IL-1α-induced apoptosis of Hep G2 cells. These results suggest that PTAE may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells.",

author = "Koo, \{H. N.\} and Jeong, \{H. J.\} and Kim, \{K. R.\} and Kim, \{J. C.\} and Kim, \{K. S.\} and Kang, \{B. K.\} and Kim, \{H. M.\} and Kim, \{J. J.\}",

year = "2000",

doi = "10.3109/08923970009026010",

language = "English",

volume = "22",

pages = "531--544",

journal = "Immunopharmacology and Immunotoxicology",

issn = "0892-3973",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Inhibitory effect of interleulin-1α-induced apoptosis by polygala tenuifolia in hep g2 cells

AU - Koo, H. N.

AU - Jeong, H. J.

AU - Kim, K. R.

AU - Kim, J. C.

AU - Kim, K. S.

AU - Kang, B. K.

AU - Kim, H. M.

AU - Kim, J. J.

PY - 2000

Y1 - 2000

N2 - A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia WILLDENOW (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 υg/ml) dose- dependently inhibited the EtOH-induced interluekin-1 α (IL-1 α) secretion. PTAE (0.01-1 γg/ml) also inhibited the EtOH- and IL-1α-induced cytotoxicity. Furthermore, we found that PTAE inhibited the IL-1α-induced apoptosis of Hep G2 cells. These results suggest that PTAE may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells.

AB - A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia WILLDENOW (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 υg/ml) dose- dependently inhibited the EtOH-induced interluekin-1 α (IL-1 α) secretion. PTAE (0.01-1 γg/ml) also inhibited the EtOH- and IL-1α-induced cytotoxicity. Furthermore, we found that PTAE inhibited the IL-1α-induced apoptosis of Hep G2 cells. These results suggest that PTAE may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells.

UR - https://www.scopus.com/pages/publications/0033624643

U2 - 10.3109/08923970009026010

DO - 10.3109/08923970009026010

M3 - Article

C2 - 10946830

AN - SCOPUS:0033624643

SN - 0892-3973

VL - 22

SP - 531

EP - 544

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 3

ER -

Inhibitory effect of interleulin-1α-induced apoptosis by polygala tenuifolia in hep g2 cells

Abstract

Access to Document

Other files and links

Fingerprint

Cite this