Inhibitory effects of stilbene derivatives from Rheum undulatum on cyclooxygenase activity

Sung Kwon Ko; Chung Ryul Lee; Hak Sung Lee; Hyun Kim; Koo Hyun Baek; Kiyoshi Tokuoka; Sung Hyun Chung

Inhibitory effects of stilbene derivatives from Rheum undulatum on cyclooxygenase activity

Sung Kwon Ko
, Chung Ryul Lee
, Hak Sung Lee
, Hyun Kim
, Koo Hyun Baek
, Kiyoshi Tokuoka
, Sung Hyun Chung

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In order to clarify the anti-thrombosis activity of rhubarb, we investigated the effect of stilbene derivatives from rhizomes of Rheum undulatum on cyclooxygenase activity. Stilbene derivatives (desoxyrhapontigenin, rhapontigenin, piceatannol) exhibited the inhibitory effects on COX-1, and desoxyrhapontigenin showed inhibitory effect on COX-2. These inhibitory effect may partially contributed to anti-thrombosis activity of rhubarb.

Original language	English
Pages (from-to)	25-27
Number of pages	3
Journal	Korean Journal of Pharmacognosy
Volume	34
Issue number	1
Publication status	Published - Mar 2003

Keywords

Cyclooxygenase
Desoxyrhapontigenin
Piceatannol
Rhapontigenin
Rheum undulatum
Stilbene derivatives

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title = "Inhibitory effects of stilbene derivatives from Rheum undulatum on cyclooxygenase activity",

abstract = "In order to clarify the anti-thrombosis activity of rhubarb, we investigated the effect of stilbene derivatives from rhizomes of Rheum undulatum on cyclooxygenase activity. Stilbene derivatives (desoxyrhapontigenin, rhapontigenin, piceatannol) exhibited the inhibitory effects on COX-1, and desoxyrhapontigenin showed inhibitory effect on COX-2. These inhibitory effect may partially contributed to anti-thrombosis activity of rhubarb.",

keywords = "Cyclooxygenase, Desoxyrhapontigenin, Piceatannol, Rhapontigenin, Rheum undulatum, Stilbene derivatives",

author = "Ko, \{Sung Kwon\} and Lee, \{Chung Ryul\} and Lee, \{Hak Sung\} and Hyun Kim and Baek, \{Koo Hyun\} and Kiyoshi Tokuoka and Chung, \{Sung Hyun\}",

year = "2003",

month = mar,

language = "English",

volume = "34",

pages = "25--27",

journal = "Korean Journal of Pharmacognosy",

issn = "0253-3073",

publisher = "Korean Society of Pharmacognosy",

number = "1",

}

TY - JOUR

T1 - Inhibitory effects of stilbene derivatives from Rheum undulatum on cyclooxygenase activity

AU - Ko, Sung Kwon

AU - Lee, Chung Ryul

AU - Lee, Hak Sung

AU - Kim, Hyun

AU - Baek, Koo Hyun

AU - Tokuoka, Kiyoshi

AU - Chung, Sung Hyun

PY - 2003/3

Y1 - 2003/3

N2 - In order to clarify the anti-thrombosis activity of rhubarb, we investigated the effect of stilbene derivatives from rhizomes of Rheum undulatum on cyclooxygenase activity. Stilbene derivatives (desoxyrhapontigenin, rhapontigenin, piceatannol) exhibited the inhibitory effects on COX-1, and desoxyrhapontigenin showed inhibitory effect on COX-2. These inhibitory effect may partially contributed to anti-thrombosis activity of rhubarb.

AB - In order to clarify the anti-thrombosis activity of rhubarb, we investigated the effect of stilbene derivatives from rhizomes of Rheum undulatum on cyclooxygenase activity. Stilbene derivatives (desoxyrhapontigenin, rhapontigenin, piceatannol) exhibited the inhibitory effects on COX-1, and desoxyrhapontigenin showed inhibitory effect on COX-2. These inhibitory effect may partially contributed to anti-thrombosis activity of rhubarb.

KW - Cyclooxygenase

KW - Desoxyrhapontigenin

KW - Piceatannol

KW - Rhapontigenin

KW - Rheum undulatum

KW - Stilbene derivatives

UR - https://www.scopus.com/pages/publications/0037361222

M3 - Article

AN - SCOPUS:0037361222

SN - 0253-3073

VL - 34

SP - 25

EP - 27

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 1

ER -

Inhibitory effects of stilbene derivatives from Rheum undulatum on cyclooxygenase activity

Abstract

Keywords

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