Abstract
The effect of aqueous extract of Xanthii fructus (XF) on mast cell-mediated allergic reaction has been investigated. XF inhibited compound 48/80-induced systemic anaphylaxis in mouse. This dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. Additionally, XF inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylatic reaction. When XF (0.1mg/ml) was added, the secretion of tumor necrosis factor-α (TNF-α) from anti-dinitrophenyl (DNP) IgE antibody-stimulated mast cells was inhibited by 56%. Our studies provide evidence that XF may be beneficial in the treatment of various types allergic diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 229-234 |
| Number of pages | 6 |
| Journal | Journal of Ethnopharmacology |
| Volume | 88 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 1 Oct 2003 |
Bibliographical note
Funding Information:The present study showed that XF pretreatment profoundly affected compound 48/80-induced systemic anaphylactic reaction. XF also inhibited the histamine release from RPMC. These results may suggest that XF has anti-anaphylactic reaction. This suggestion is supported by the study of IgE-dependent cutaneous reaction. By addition of XF, the secretion of TNF-α in anti-DNP IgE antibody-stimulated mast cells was also inhibited. TNF-α inhibition rate showed bell shape, as the XF concentration varies.
Keywords
- PCA
- RPMC
- Systemic anaphylaxis
- Tumor necrosis factor-α
- Xanthii fructus
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