Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum

Xing Fu Cai; Seon Lee Im; Tien Dat Nguyen; Guanghai Shen; Seong Kang Jong; Hyun Kim Dong; Ho Kim Young

doi:10.1007/BF02980142

Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum

Xing Fu Cai
, Seon Lee Im
, Tien Dat Nguyen
, Guanghai Shen
, Seong Kang Jong
, Hyun Kim Dong
, Ho Kim Young

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC₅₀: 36.3 ± 2.5 μM). However, the activities of 1 (IC₅₀: > 500 μM) and 2 (IC ₅₀: 136.1 ± 9.4 μM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.

Original language	English
Pages (from-to)	738-741
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	27
Issue number	7
DOIs	https://doi.org/10.1007/BF02980142
Publication status	Published - 31 Jul 2004

Bibliographical note

Funding Information:
This study was supported by a grant from the Basic Research Program of the Korea Science & Engineering Foundation (R05-2001-00026). We are grateful to KBSI for supplying the NMR and MS spectra.

Keywords

Acanthopanax koreanum
Araliaceae
Inhibitory effect
Lignan
NFAT transcription factor

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10.1007/BF02980142

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@article{d05c63e6570e453d88feb3c3fe301955,

title = "Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum",

abstract = "Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 ± 2.5 μM). However, the activities of 1 (IC50: > 500 μM) and 2 (IC 50: 136.1 ± 9.4 μM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.",

keywords = "Acanthopanax koreanum, Araliaceae, Inhibitory effect, Lignan, NFAT transcription factor",

author = "Cai, \{Xing Fu\} and Im, \{Seon Lee\} and Nguyen, \{Tien Dat\} and Guanghai Shen and Jong, \{Seong Kang\} and Dong, \{Hyun Kim\} and Young, \{Ho Kim\}",

note = "Funding Information: This study was supported by a grant from the Basic Research Program of the Korea Science \& Engineering Foundation (R05-2001-00026). We are grateful to KBSI for supplying the NMR and MS spectra.",

year = "2004",

month = jul,

day = "31",

doi = "10.1007/BF02980142",

language = "English",

volume = "27",

pages = "738--741",

journal = "Archives of Pharmacal Research",

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publisher = "Pharmaceutical Society of Korea",

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TY - JOUR

T1 - Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum

AU - Cai, Xing Fu

AU - Im, Seon Lee

AU - Nguyen, Tien Dat

AU - Shen, Guanghai

AU - Jong, Seong Kang

AU - Dong, Hyun Kim

AU - Young, Ho Kim

N1 - Funding Information: This study was supported by a grant from the Basic Research Program of the Korea Science & Engineering Foundation (R05-2001-00026). We are grateful to KBSI for supplying the NMR and MS spectra.

PY - 2004/7/31

Y1 - 2004/7/31

N2 - Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 ± 2.5 μM). However, the activities of 1 (IC50: > 500 μM) and 2 (IC 50: 136.1 ± 9.4 μM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.

AB - Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 ± 2.5 μM). However, the activities of 1 (IC50: > 500 μM) and 2 (IC 50: 136.1 ± 9.4 μM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.

KW - Acanthopanax koreanum

KW - Araliaceae

KW - Inhibitory effect

KW - Lignan

KW - NFAT transcription factor

UR - https://www.scopus.com/pages/publications/16644382410

U2 - 10.1007/BF02980142

DO - 10.1007/BF02980142

M3 - Article

C2 - 15357001

AN - SCOPUS:16644382410

SN - 0253-6269

VL - 27

SP - 738

EP - 741

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 7

ER -

Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum

Abstract

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Keywords

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