Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor

So Young Jang; Yoon Kyung Shin; Junyang Jung; Sang Hwa Lee; Su Yeong Seo; Duk Joon Suh; Hwan Tae Park

doi:10.1016/j.neulet.2010.08.058

Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor

So Young Jang
, Yoon Kyung Shin
, Junyang Jung
, Sang Hwa Lee
, Su Yeong Seo
, Duk Joon Suh
, Hwan Tae Park

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Neurotrophic cytokines, such as ciliary neurotrophic factor (CNTF) play an important role in the development and regeneration of the nervous system. In the present study, we screened gene expression induced by CNTF in adult dorsal root ganglion (DRG) neurons using the Illumina microarray. We found that the expression of both short and long forms of collapsin response-mediator protein 4 (CRMP4) was increased in cultured primary sensory neurons by CNTF. In addition, sciatic nerve injury induced the expression of CRMP4 mRNA and protein in DRG neurons. Finally, the increased CRMP4 protein was transported into peripheral axons following nerve injury. These findings indicate that CRMP4 may be a target gene for CNTF in the regenerative axon growth of DRG neurons after injury.

Original language	English
Pages (from-to)	37-42
Number of pages	6
Journal	Neuroscience Letters
Volume	485
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2010.08.058
Publication status	Published - Nov 2010

Bibliographical note

Funding Information:
This research was supported by Mid-career Research Program and Science Research Center through NRF grant funded by the Ministry of Education, Science and Technology of Republic of Korea (2010-0000132, 2010-0001945).

Keywords

Ciliary neurotrophic factor
Collapsin response-mediator protein 4
Dorsal root ganglion
Sciatic nerve injury

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10.1016/j.neulet.2010.08.058

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title = "Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor",

abstract = "Neurotrophic cytokines, such as ciliary neurotrophic factor (CNTF) play an important role in the development and regeneration of the nervous system. In the present study, we screened gene expression induced by CNTF in adult dorsal root ganglion (DRG) neurons using the Illumina microarray. We found that the expression of both short and long forms of collapsin response-mediator protein 4 (CRMP4) was increased in cultured primary sensory neurons by CNTF. In addition, sciatic nerve injury induced the expression of CRMP4 mRNA and protein in DRG neurons. Finally, the increased CRMP4 protein was transported into peripheral axons following nerve injury. These findings indicate that CRMP4 may be a target gene for CNTF in the regenerative axon growth of DRG neurons after injury.",

keywords = "Ciliary neurotrophic factor, Collapsin response-mediator protein 4, Dorsal root ganglion, Sciatic nerve injury",

author = "Jang, \{So Young\} and Shin, \{Yoon Kyung\} and Junyang Jung and Lee, \{Sang Hwa\} and Seo, \{Su Yeong\} and Suh, \{Duk Joon\} and Park, \{Hwan Tae\}",

note = "Funding Information: This research was supported by Mid-career Research Program and Science Research Center through NRF grant funded by the Ministry of Education, Science and Technology of Republic of Korea (2010-0000132, 2010-0001945).",

year = "2010",

month = nov,

doi = "10.1016/j.neulet.2010.08.058",

language = "English",

volume = "485",

pages = "37--42",

journal = "Neuroscience Letters",

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AU - Jang, So Young

AU - Shin, Yoon Kyung

AU - Jung, Junyang

AU - Lee, Sang Hwa

AU - Seo, Su Yeong

AU - Suh, Duk Joon

AU - Park, Hwan Tae

N1 - Funding Information: This research was supported by Mid-career Research Program and Science Research Center through NRF grant funded by the Ministry of Education, Science and Technology of Republic of Korea (2010-0000132, 2010-0001945).

PY - 2010/11

Y1 - 2010/11

N2 - Neurotrophic cytokines, such as ciliary neurotrophic factor (CNTF) play an important role in the development and regeneration of the nervous system. In the present study, we screened gene expression induced by CNTF in adult dorsal root ganglion (DRG) neurons using the Illumina microarray. We found that the expression of both short and long forms of collapsin response-mediator protein 4 (CRMP4) was increased in cultured primary sensory neurons by CNTF. In addition, sciatic nerve injury induced the expression of CRMP4 mRNA and protein in DRG neurons. Finally, the increased CRMP4 protein was transported into peripheral axons following nerve injury. These findings indicate that CRMP4 may be a target gene for CNTF in the regenerative axon growth of DRG neurons after injury.

AB - Neurotrophic cytokines, such as ciliary neurotrophic factor (CNTF) play an important role in the development and regeneration of the nervous system. In the present study, we screened gene expression induced by CNTF in adult dorsal root ganglion (DRG) neurons using the Illumina microarray. We found that the expression of both short and long forms of collapsin response-mediator protein 4 (CRMP4) was increased in cultured primary sensory neurons by CNTF. In addition, sciatic nerve injury induced the expression of CRMP4 mRNA and protein in DRG neurons. Finally, the increased CRMP4 protein was transported into peripheral axons following nerve injury. These findings indicate that CRMP4 may be a target gene for CNTF in the regenerative axon growth of DRG neurons after injury.

KW - Ciliary neurotrophic factor

KW - Collapsin response-mediator protein 4

KW - Dorsal root ganglion

KW - Sciatic nerve injury

UR - https://www.scopus.com/pages/publications/77957233014

U2 - 10.1016/j.neulet.2010.08.058

DO - 10.1016/j.neulet.2010.08.058

M3 - Article

C2 - 20800647

AN - SCOPUS:77957233014

SN - 0304-3940

VL - 485

SP - 37

EP - 42

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor

Abstract

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Keywords

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