Intersection of genetics and epigenetics in monozygotic twin genomes

Kwoneel Kim; Kibaick Lee; Hyoeun Bang; Jeong Yeon Kim; Jung Kyoon Choi

doi:10.1016/j.ymeth.2015.10.020

Intersection of genetics and epigenetics in monozygotic twin genomes

Kwoneel Kim
, Kibaick Lee
, Hyoeun Bang
, Jeong Yeon Kim
, Jung Kyoon Choi

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

As a final function of various epigenetic mechanisms, chromatin regulation is a transcription control process that especially demonstrates active interaction with genetic elements. Thus, chromatin structure has become a principal focus in recent genomics researches that strive to characterize regulatory functions of DNA variants related to diseases or other traits. Although researchers have been focusing on DNA methylation when studying monozygotic (MZ) twins, a great model in epigenetics research, interactions between genetics and epigenetics in chromatin level are expected to be an imperative research trend in the future. In this review, we discuss how the genome, epigenome, and transcriptome of MZ twins can be studied in an integrative manner from this perspective.

Original language	English
Pages (from-to)	50-56
Number of pages	7
Journal	Methods
Volume	102
DOIs	https://doi.org/10.1016/j.ymeth.2015.10.020
Publication status	Published - 1 Jun 2016

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© 2015 Elsevier Inc.

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10.1016/j.ymeth.2015.10.020

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title = "Intersection of genetics and epigenetics in monozygotic twin genomes",

abstract = "As a final function of various epigenetic mechanisms, chromatin regulation is a transcription control process that especially demonstrates active interaction with genetic elements. Thus, chromatin structure has become a principal focus in recent genomics researches that strive to characterize regulatory functions of DNA variants related to diseases or other traits. Although researchers have been focusing on DNA methylation when studying monozygotic (MZ) twins, a great model in epigenetics research, interactions between genetics and epigenetics in chromatin level are expected to be an imperative research trend in the future. In this review, we discuss how the genome, epigenome, and transcriptome of MZ twins can be studied in an integrative manner from this perspective.",

author = "Kwoneel Kim and Kibaick Lee and Hyoeun Bang and Kim, \{Jeong Yeon\} and Choi, \{Jung Kyoon\}",

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doi = "10.1016/j.ymeth.2015.10.020",

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T1 - Intersection of genetics and epigenetics in monozygotic twin genomes

AU - Kim, Kwoneel

AU - Lee, Kibaick

AU - Bang, Hyoeun

AU - Kim, Jeong Yeon

AU - Choi, Jung Kyoon

PY - 2016/6/1

Y1 - 2016/6/1

N2 - As a final function of various epigenetic mechanisms, chromatin regulation is a transcription control process that especially demonstrates active interaction with genetic elements. Thus, chromatin structure has become a principal focus in recent genomics researches that strive to characterize regulatory functions of DNA variants related to diseases or other traits. Although researchers have been focusing on DNA methylation when studying monozygotic (MZ) twins, a great model in epigenetics research, interactions between genetics and epigenetics in chromatin level are expected to be an imperative research trend in the future. In this review, we discuss how the genome, epigenome, and transcriptome of MZ twins can be studied in an integrative manner from this perspective.

AB - As a final function of various epigenetic mechanisms, chromatin regulation is a transcription control process that especially demonstrates active interaction with genetic elements. Thus, chromatin structure has become a principal focus in recent genomics researches that strive to characterize regulatory functions of DNA variants related to diseases or other traits. Although researchers have been focusing on DNA methylation when studying monozygotic (MZ) twins, a great model in epigenetics research, interactions between genetics and epigenetics in chromatin level are expected to be an imperative research trend in the future. In this review, we discuss how the genome, epigenome, and transcriptome of MZ twins can be studied in an integrative manner from this perspective.

UR - https://www.scopus.com/pages/publications/84964523840

U2 - 10.1016/j.ymeth.2015.10.020

DO - 10.1016/j.ymeth.2015.10.020

M3 - Review article

C2 - 26548893

AN - SCOPUS:84964523840

SN - 1046-2023

VL - 102

SP - 50

EP - 56

JO - Methods

JF - Methods

ER -

Intersection of genetics and epigenetics in monozygotic twin genomes

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