Introduction to single-cell dna methylation profiling methods

Jongseong Ahn; Sunghoon Heo; Jihyun Lee; Duhee Bang

doi:10.3390/biom11071013

Introduction to single-cell dna methylation profiling methods

Jongseong Ahn
, Sunghoon Heo
, Jihyun Lee
, Duhee Bang

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells. In this review, we introduce single-cell DNA-methylation profiling methods, including experimental strategies and approaches to computational data analysis. Furthermore, the blind spots of the basic analysis and recent alternatives are briefly described. In addition, we introduce well-known applications and discuss future development.

Original language	English
Article number	1013
Journal	Biomolecules
Volume	11
Issue number	7
DOIs	https://doi.org/10.3390/biom11071013
Publication status	Published - Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Bioinformatics
DNA methylation
Single cell

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10.3390/biom11071013

Cite this

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abstract = "DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells. In this review, we introduce single-cell DNA-methylation profiling methods, including experimental strategies and approaches to computational data analysis. Furthermore, the blind spots of the basic analysis and recent alternatives are briefly described. In addition, we introduce well-known applications and discuss future development.",

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AU - Lee, Jihyun

AU - Bang, Duhee

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N2 - DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells. In this review, we introduce single-cell DNA-methylation profiling methods, including experimental strategies and approaches to computational data analysis. Furthermore, the blind spots of the basic analysis and recent alternatives are briefly described. In addition, we introduce well-known applications and discuss future development.

AB - DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells. In this review, we introduce single-cell DNA-methylation profiling methods, including experimental strategies and approaches to computational data analysis. Furthermore, the blind spots of the basic analysis and recent alternatives are briefly described. In addition, we introduce well-known applications and discuss future development.

KW - Bioinformatics

KW - DNA methylation

KW - Single cell

UR - https://www.scopus.com/pages/publications/85109374852

U2 - 10.3390/biom11071013

DO - 10.3390/biom11071013

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JO - Biomolecules

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Introduction to single-cell dna methylation profiling methods

Abstract

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Keywords

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