Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug

Pharmacology, Toxicology and Pharmaceutical Science

• Adjuvant Arthritis 80%
• Adjuvant-Induced Arthritis 80%
• Disease Exacerbation 20%
• Drug Repositioning 20%
• Inflammatory Arthritis 100%
• Inflammatory Disease 20%
• Interleukin 6 60%
• Interstitial Collagenase 20%
• Polyinosinic Polycytidylic Acid 20%
• Rat Model 40%
• Rheumatoid Arthritis 100%
• Therapeutic Effect 20%
• Toll Like Receptor 20%
• Toll Like Receptor 3 20%
• Toll Like Receptor 4 100%
• Vasculotropin 40%

Immunology and Microbiology

• Arthritis 80%
• Blood Level 20%
• Body Weight 20%
• Fibroblast-Like Synoviocyte 80%
• Inflammatory Arthritis 100%
• Inflammatory Disorder 20%
• Interleukin 6 60%
• Interleukin 8 40%
• Interleukin-1 20%
• Polyinosinic:polycytidylic Acid 20%
• Rat Model 40%
• Reverse Transcription Polymerase Chain Reaction 20%
• Signal Transduction 20%
• TLR3 20%
• TLR4 100%
• Toll-Like Receptor 20%
• Vasculotropin 40%