TY - JOUR
T1 - Linking Chinese medicine and G-protein-coupled receptors
AU - Im, Dong Soon
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Following the purification of the immunosuppressant ISP-1 from a Chinese medicine, Japanese scientists have developed a more potent immune modulator, FTY720, that induces T-cell homing. FTY720, a promising immunosuppressant for use in patients with tissue transplants and autoimmune diseases, is currently in clinical trials. Two recent studies have elucidated that the mechanism of action of FTY720 is via a subset of G-protein-coupled receptors for the lysophospholipid mediator sphingosine-1-phosphate.
AB - Following the purification of the immunosuppressant ISP-1 from a Chinese medicine, Japanese scientists have developed a more potent immune modulator, FTY720, that induces T-cell homing. FTY720, a promising immunosuppressant for use in patients with tissue transplants and autoimmune diseases, is currently in clinical trials. Two recent studies have elucidated that the mechanism of action of FTY720 is via a subset of G-protein-coupled receptors for the lysophospholipid mediator sphingosine-1-phosphate.
UR - http://www.scopus.com/inward/record.url?scp=0037216604&partnerID=8YFLogxK
U2 - 10.1016/S0165-6147(02)00012-3
DO - 10.1016/S0165-6147(02)00012-3
M3 - Short survey
C2 - 12498721
AN - SCOPUS:0037216604
SN - 0165-6147
VL - 24
SP - 2
EP - 4
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -