Mechanisms of the Anticancer Effects of Isothiocyanates

Neel M. Fofaria; Alok Ranjan; Sung Hoon Kim; Sanjay K. Srivastava

doi:10.1016/bs.enz.2015.06.001

Mechanisms of the Anticancer Effects of Isothiocyanates

Neel M. Fofaria, Alok Ranjan, Sung Hoon Kim, Sanjay K. Srivastava

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

43 Citations (Scopus)

Abstract

Cancer results from aberrant signaling pathways that result in uncontrolled cellular proliferation. The epidemiological studies have shown a strong inverse correlation between dietary consumption of cruciferous vegetables and incidences of cancer. Isothiocyanates (ITCs) are present in cruciferous vegetables like broccoli, cabbage, watercress, etc. and are identified as the major active constituents. Several mechanistic studies have demonstrated chemopreventive and chemotherapeutic activity of ITCs against various tumor types. ITCs exert anticancer activity by suppressing various critical hallmarks of cancer like cellular proliferation, angiogenesis, apoptosis, metastasis, etc., in vitro as well as in preclinical animal model. ITCs also generate reactive oxygen species to induce apoptosis in cancer cells. Due to promising preclinical results, few ITCs have also advanced to clinical trials. This chapter provides a candid review on the chemopreventive and chemotherapeutic activity of various major ITCs.

Original language	English
Title of host publication	Mechanism of the Anticancer Effect of Phytochemicals, 2015
Editors	Fuyuhiko Tamanoi, S. Zahra Bathaie
Publisher	Academic Press
Pages	111-137
Number of pages	27
ISBN (Print)	9780128038765
DOIs	https://doi.org/10.1016/bs.enz.2015.06.001
Publication status	Published - 2015

Publication series

Name	Enzymes
Volume	37
ISSN (Print)	1874-6047

Bibliographical note

Funding Information:
This work was supported in part by R01 grant CA129038 (to S.K.S.) awarded by the National Cancer Institute, NIH, and MEST grant 2012–0005755 (to S.H.K.) by Korean government. Funds from Texas Tech University Health Science Center are also acknowledged. S.K.S. is currently an International Scholar at Kyung Hee University, Seoul, South Korea.

Keywords

BITC
Cancer
Isothiocyanate
PEITC
Sulforaphane

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/bs.enz.2015.06.001

Cite this

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title = "Mechanisms of the Anticancer Effects of Isothiocyanates",

abstract = "Cancer results from aberrant signaling pathways that result in uncontrolled cellular proliferation. The epidemiological studies have shown a strong inverse correlation between dietary consumption of cruciferous vegetables and incidences of cancer. Isothiocyanates (ITCs) are present in cruciferous vegetables like broccoli, cabbage, watercress, etc. and are identified as the major active constituents. Several mechanistic studies have demonstrated chemopreventive and chemotherapeutic activity of ITCs against various tumor types. ITCs exert anticancer activity by suppressing various critical hallmarks of cancer like cellular proliferation, angiogenesis, apoptosis, metastasis, etc., in vitro as well as in preclinical animal model. ITCs also generate reactive oxygen species to induce apoptosis in cancer cells. Due to promising preclinical results, few ITCs have also advanced to clinical trials. This chapter provides a candid review on the chemopreventive and chemotherapeutic activity of various major ITCs.",

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author = "Fofaria, {Neel M.} and Alok Ranjan and Kim, {Sung Hoon} and Srivastava, {Sanjay K.}",

note = "Funding Information: This work was supported in part by R01 grant CA129038 (to S.K.S.) awarded by the National Cancer Institute, NIH, and MEST grant 2012–0005755 (to S.H.K.) by Korean government. Funds from Texas Tech University Health Science Center are also acknowledged. S.K.S. is currently an International Scholar at Kyung Hee University, Seoul, South Korea. ",

year = "2015",

doi = "10.1016/bs.enz.2015.06.001",

language = "English",

isbn = "9780128038765",

series = "Enzymes",

publisher = "Academic Press",

pages = "111--137",

editor = "Fuyuhiko Tamanoi and Bathaie, {S. Zahra}",

booktitle = "Mechanism of the Anticancer Effect of Phytochemicals, 2015",

}

Mechanisms of the Anticancer Effects of Isothiocyanates. / Fofaria, Neel M.; Ranjan, Alok; Kim, Sung Hoon et al.
Mechanism of the Anticancer Effect of Phytochemicals, 2015. ed. / Fuyuhiko Tamanoi; S. Zahra Bathaie. Academic Press, 2015. p. 111-137 (Enzymes; Vol. 37).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Srivastava, Sanjay K.

N1 - Funding Information: This work was supported in part by R01 grant CA129038 (to S.K.S.) awarded by the National Cancer Institute, NIH, and MEST grant 2012–0005755 (to S.H.K.) by Korean government. Funds from Texas Tech University Health Science Center are also acknowledged. S.K.S. is currently an International Scholar at Kyung Hee University, Seoul, South Korea.

PY - 2015

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AB - Cancer results from aberrant signaling pathways that result in uncontrolled cellular proliferation. The epidemiological studies have shown a strong inverse correlation between dietary consumption of cruciferous vegetables and incidences of cancer. Isothiocyanates (ITCs) are present in cruciferous vegetables like broccoli, cabbage, watercress, etc. and are identified as the major active constituents. Several mechanistic studies have demonstrated chemopreventive and chemotherapeutic activity of ITCs against various tumor types. ITCs exert anticancer activity by suppressing various critical hallmarks of cancer like cellular proliferation, angiogenesis, apoptosis, metastasis, etc., in vitro as well as in preclinical animal model. ITCs also generate reactive oxygen species to induce apoptosis in cancer cells. Due to promising preclinical results, few ITCs have also advanced to clinical trials. This chapter provides a candid review on the chemopreventive and chemotherapeutic activity of various major ITCs.

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ER -

Mechanisms of the Anticancer Effects of Isothiocyanates

Abstract

Publication series

Bibliographical note

Keywords

UN SDGs

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