Membrane permeable esterase-activated fluorescent imaging probe

Youngmi Kim; Yongdoo Choi; Ralph Weissleder; Ching Hsuan Tung

doi:10.1016/j.bmcl.2007.07.026

Membrane permeable esterase-activated fluorescent imaging probe

Youngmi Kim, Yongdoo Choi, Ralph Weissleder, Ching Hsuan Tung

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

An esterase-triggered probe 2 derived from a cyanine-based pH sensitive dye was developed for cell labeling. Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal.

Original language	English
Pages (from-to)	5054-5057
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2007.07.026
Publication status	Published - 15 Sep 2007

Keywords

Esterase
Fluorescent
Imaging probe

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10.1016/j.bmcl.2007.07.026

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@article{2db9545e507f46198c5ec100423350ce,

title = "Membrane permeable esterase-activated fluorescent imaging probe",

abstract = "An esterase-triggered probe 2 derived from a cyanine-based pH sensitive dye was developed for cell labeling. Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal.",

keywords = "Esterase, Fluorescent, Imaging probe",

author = "Youngmi Kim and Yongdoo Choi and Ralph Weissleder and Tung, {Ching Hsuan}",

note = "Funding Information: This research was supported in part by NIH P50-CA86355, RO1 CA099385, and R33 CA114149. ",

year = "2007",

month = sep,

day = "15",

doi = "10.1016/j.bmcl.2007.07.026",

language = "English",

volume = "17",

pages = "5054--5057",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "18",

}

TY - JOUR

T1 - Membrane permeable esterase-activated fluorescent imaging probe

AU - Kim, Youngmi

AU - Choi, Yongdoo

AU - Weissleder, Ralph

AU - Tung, Ching Hsuan

N1 - Funding Information: This research was supported in part by NIH P50-CA86355, RO1 CA099385, and R33 CA114149.

PY - 2007/9/15

Y1 - 2007/9/15

N2 - An esterase-triggered probe 2 derived from a cyanine-based pH sensitive dye was developed for cell labeling. Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal.

AB - An esterase-triggered probe 2 derived from a cyanine-based pH sensitive dye was developed for cell labeling. Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal.

KW - Esterase

KW - Fluorescent

KW - Imaging probe

UR - http://www.scopus.com/inward/record.url?scp=34547863487&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2007.07.026

DO - 10.1016/j.bmcl.2007.07.026

M3 - Article

C2 - 17664067

AN - SCOPUS:34547863487

VL - 17

SP - 5054

EP - 5057

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 18

ER -

Membrane permeable esterase-activated fluorescent imaging probe

Abstract

Keywords

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