Membrane permeable esterase-activated fluorescent imaging probe

Youngmi Kim, Yongdoo Choi, Ralph Weissleder, Ching Hsuan Tung

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


An esterase-triggered probe 2 derived from a cyanine-based pH sensitive dye was developed for cell labeling. Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal.

Original languageEnglish
Pages (from-to)5054-5057
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number18
Publication statusPublished - 15 Sep 2007


  • Esterase
  • Fluorescent
  • Imaging probe


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