Mesonephric-like carcinoma of the uterine corpus: A case report and literature review

This report describes a woman with uterine mesonephric-like carcinoma and reviews the literature on this rare condition. A 60-year-old woman was referred for abdominal discomfort. Pelvic magnetic resonance imaging showed a tumor, about 7.0 cm in diameter in her left ovary. Surgical exploration, however, showed that both ovaries were grossly free of tumor. Rather, a protruding cancerous mass was found on the left side of her uterus. The tumor was composed of cells with various growth patterns and was diffusely positive for PAX8 and GATA3 on immunohistochemistry. The apical luminal border of the glandular structures was positive for CD10, and the glandular structures were focally positive for EMA. The final diagnosis was mesonephric-like carcinoma, stage pT3N1M. Conclusion: Diagnosing mesonephric-like carcinoma is pathologically challenging because these tumors are rare and present with a wide spectrum of morphologic patterns. Positive staining for PAX8 and GATA3 and a luminal staining pattern of CD10 can support the diagnosis.