Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities

Eun Ah Bae; Chang Soo Yook; O. Jin Oh; Seung Yeup Chang; Toshihiro Nohara; Dong Hyun Kim

doi:10.1248/bpb.24.582

Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities

Eun Ah Bae, Chang Soo Yook, O. Jin Oh, Seung Yeup Chang, Toshihiro Nohara, Dong Hyun Kim

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The metabolic pathway of chiisanoside isolated from leaves of Acanthopanax divaricatus var. albeofructus (Araliaceae) by human intestinal bacteria and by the protein fraction of leaves of this plant were investigated, and the cytotoxic and anti-rotaviral activities of chiisanoside and its metabolite, chiisanogenin, were assayed. Chiisanogenin was produced as a main metabolite, when chiisanoside were incubated for 15 h with human intestinal bacteria. This metabolic pathway proceeded more potently with the protein fraction than with human intestinal bacteria. The in vitro cytotoxicity of chiisanogenin was superior to that of chiisanoside. H⁺/K⁺ ATPase was more potently inhibited by chiisanogenin than by chiisanoside. However, the anti-rotaviral activity of chiisanoside was more potent than that of chiisanogenin.

Original language	English
Pages (from-to)	582-585
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	24
Issue number	5
DOIs	https://doi.org/10.1248/bpb.24.582
Publication status	Published - 2001

Keywords

Acanthopanax divaricatus var. albeofructus
Biological activity
Chiisanoside
Human intestinal bacteria

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10.1248/bpb.24.582

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title = "Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities",

abstract = "The metabolic pathway of chiisanoside isolated from leaves of Acanthopanax divaricatus var. albeofructus (Araliaceae) by human intestinal bacteria and by the protein fraction of leaves of this plant were investigated, and the cytotoxic and anti-rotaviral activities of chiisanoside and its metabolite, chiisanogenin, were assayed. Chiisanogenin was produced as a main metabolite, when chiisanoside were incubated for 15 h with human intestinal bacteria. This metabolic pathway proceeded more potently with the protein fraction than with human intestinal bacteria. The in vitro cytotoxicity of chiisanogenin was superior to that of chiisanoside. H+/K+ ATPase was more potently inhibited by chiisanogenin than by chiisanoside. However, the anti-rotaviral activity of chiisanoside was more potent than that of chiisanogenin.",

keywords = "Acanthopanax divaricatus var. albeofructus, Biological activity, Chiisanoside, Human intestinal bacteria",

author = "Bae, {Eun Ah} and Yook, {Chang Soo} and Oh, {O. Jin} and Chang, {Seung Yeup} and Toshihiro Nohara and Kim, {Dong Hyun}",

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AU - Bae, Eun Ah

AU - Yook, Chang Soo

AU - Oh, O. Jin

AU - Chang, Seung Yeup

AU - Nohara, Toshihiro

AU - Kim, Dong Hyun

PY - 2001

Y1 - 2001

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AB - The metabolic pathway of chiisanoside isolated from leaves of Acanthopanax divaricatus var. albeofructus (Araliaceae) by human intestinal bacteria and by the protein fraction of leaves of this plant were investigated, and the cytotoxic and anti-rotaviral activities of chiisanoside and its metabolite, chiisanogenin, were assayed. Chiisanogenin was produced as a main metabolite, when chiisanoside were incubated for 15 h with human intestinal bacteria. This metabolic pathway proceeded more potently with the protein fraction than with human intestinal bacteria. The in vitro cytotoxicity of chiisanogenin was superior to that of chiisanoside. H+/K+ ATPase was more potently inhibited by chiisanogenin than by chiisanoside. However, the anti-rotaviral activity of chiisanoside was more potent than that of chiisanogenin.

KW - Acanthopanax divaricatus var. albeofructus

KW - Biological activity

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KW - Human intestinal bacteria

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Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities

Abstract

Keywords

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