Abstract
When quercitrin was anaerobically incubated with human intestinal bacteria, quercetin, 3,4-dihydroxyphenylacetic acid and 4-hydroxybenzoic acid were found as metabolites. The main metabolite was quercetin. The bacterium transforming quercitrin to quercetin was Fusobacterium K-60. However, Bacteroides JY-6, which produced α-L-rhamnosidase, did not transform quercitrin to quercetin. Among quercitrin and its metabolites, 3,4- dihydroxyphenylacetic acid and 4-hydroxylphenylacetic acid had more potent activity than quercitrin on in vitro anti-platelet aggregation activity, and quercetin and 3,4-dihydroxyphenylacetic acid showed more potent cytotoxicity against tumor cell lines than quercitrin and 4-hydroxylphenylacetic acid.
| Original language | English |
|---|---|
| Pages (from-to) | 749-751 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1999 |
Keywords
- Anti-platelet aggregation
- Cytotoxicity
- Fusobacterium K-60
- Intestinal bacteria
- Quercitrin
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