Metabolomics in the natural products field - A gateway to novel antibiotics

Changsheng Wu, Hye Kyong Kim, Gilles P. Van Wezel, Young Hae Choi

Research output: Contribution to journalReview articlepeer-review

76 Citations (Scopus)

Abstract

Metabolomics is a high throughput analytical technique used to globally measure low molecular weight metabolites, allowing simultaneous metabolic comparison of different biological samples and thus highlighting differentially produced compounds as potential biomarkers. Although microbes are renowned as prolific sources of antibiotics, the traditional approach for new anti-infectives discovery is time-consuming and labor-intensive. In this review, the use of NMR- or MS-based metabolomics is proposed as an efficient approach to find antimicrobials in microbial single- or co-cultures.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalDrug Discovery Today: Technologies
Volume13
DOIs
Publication statusPublished - 1 Jun 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

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