TY - JOUR
T1 - Nanoarchitectured peroxidase-mimetic nanozymes
T2 - Mesoporous nanocrystalline α- Or γ-iron oxide?
AU - Masud, Mostafa Kamal
AU - Kim, Jeonghun
AU - Billah, Md Motasim
AU - Wood, Kathleen
AU - Shiddiky, Mohammad J.A.
AU - Nguyen, Nam Trung
AU - Parsapur, Rajesh Kumar
AU - Kaneti, Yusuf Valentino
AU - Alshehri, Abdulmohsen Ali
AU - Alghamidi, Yousef Gamaan
AU - Alzahrani, Khalid Ahmed
AU - Adharvanachari, Murugulla
AU - Selvam, Parasuraman
AU - Hossain, Md Shahriar A.
AU - Yamauchi, Yusuke
N1 - Publisher Copyright:
© 2019 The Royal Society of Chemistry.
PY - 2019
Y1 - 2019
N2 - Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe2O3 and α-Fe2O3) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe2O3 shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe2O3. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.
AB - Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe2O3 and α-Fe2O3) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe2O3 shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe2O3. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.
UR - http://www.scopus.com/inward/record.url?scp=85072030759&partnerID=8YFLogxK
U2 - 10.1039/c9tb00989b
DO - 10.1039/c9tb00989b
M3 - Article
C2 - 31414694
AN - SCOPUS:85072030759
SN - 2050-7518
VL - 7
SP - 5412
EP - 5422
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 35
ER -