Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes

Jae Hyung Park; Kang Moo Huh; Sang Cheon Lee; Woo Kyoung Lee; Tooru Ooya; Kinam Park

Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes

Jae Hyung Park, Kang Moo Huh, Sang Cheon Lee, Woo Kyoung Lee, Tooru Ooya, Kinam Park

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Citations (Scopus)

Abstract

Nanoparticulates, composed of hydrotropic polymers, dentrimers, or polymer complexes, were developed to deliver poorly water-soluble drugs. Nanoparticulate polymer systems were also developed for encapsulation of proteins. Hydrotropic amphiphilic block copolymers self-associated to form nanosized micelles in an aqueous solution. The hydrotropic micelles containing hydrotroperich cores exhibited not only high loading capacity of paclitaxel but also enhanced physical stability in aqueous media. Polyglycerol dendrimers increased the water solubility of paclitaxel by several orders of magnitude due to the presence of a high local density of ethylene glycol units having the hydrotropic property. The hydrogel nanoparticles were also prepared by simple mixing of two polymer solutions.

Original language	English
Title of host publication	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
Editors	M. Laudon, B. Romanowicz
Pages	124-127
Number of pages	4
Publication status	Published - 2005
Event	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States Duration: 8 May 2005 → 12 May 2005

Publication series

Name	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Conference

Conference	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
Country/Territory	United States
City	Anaheim, CA
Period	8/05/05 → 12/05/05

Keywords

Dendrimer
Hydrogel
Hydrotropic copolymer
Polymer micelle

Cite this

Park, J. H., Huh, K. M., Lee, S. C., Lee, W. K., Ooya, T., & Park, K. (2005). Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes. In M. Laudon, & B. Romanowicz (Eds.), 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings (pp. 124-127). (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).

Park, Jae Hyung ; Huh, Kang Moo ; Lee, Sang Cheon et al. / Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes. 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings. editor / M. Laudon ; B. Romanowicz. 2005. pp. 124-127 (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).

@inproceedings{eaf5e7ba3c584ae2af5e9fa6bd838f6b,

title = "Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes",

abstract = "Nanoparticulates, composed of hydrotropic polymers, dentrimers, or polymer complexes, were developed to deliver poorly water-soluble drugs. Nanoparticulate polymer systems were also developed for encapsulation of proteins. Hydrotropic amphiphilic block copolymers self-associated to form nanosized micelles in an aqueous solution. The hydrotropic micelles containing hydrotroperich cores exhibited not only high loading capacity of paclitaxel but also enhanced physical stability in aqueous media. Polyglycerol dendrimers increased the water solubility of paclitaxel by several orders of magnitude due to the presence of a high local density of ethylene glycol units having the hydrotropic property. The hydrogel nanoparticles were also prepared by simple mixing of two polymer solutions.",

keywords = "Dendrimer, Hydrogel, Hydrotropic copolymer, Polymer micelle",

author = "Park, {Jae Hyung} and Huh, {Kang Moo} and Lee, {Sang Cheon} and Lee, {Woo Kyoung} and Tooru Ooya and Kinam Park",

year = "2005",

language = "English",

isbn = "0976798506",

series = "2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings",

pages = "124--127",

editor = "M. Laudon and B. Romanowicz",

booktitle = "2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings",

}

Park, JH, Huh, KM, Lee, SC, Lee, WK, Ooya, T & Park, K 2005, Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes. in M Laudon & B Romanowicz (eds), 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings. 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings, pp. 124-127, 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005, Anaheim, CA, United States, 8/05/05.

Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes. / Park, Jae Hyung; Huh, Kang Moo; Lee, Sang Cheon et al.
2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings. ed. / M. Laudon; B. Romanowicz. 2005. p. 124-127 (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes

AU - Park, Jae Hyung

AU - Huh, Kang Moo

AU - Lee, Sang Cheon

AU - Lee, Woo Kyoung

AU - Ooya, Tooru

AU - Park, Kinam

PY - 2005

Y1 - 2005

N2 - Nanoparticulates, composed of hydrotropic polymers, dentrimers, or polymer complexes, were developed to deliver poorly water-soluble drugs. Nanoparticulate polymer systems were also developed for encapsulation of proteins. Hydrotropic amphiphilic block copolymers self-associated to form nanosized micelles in an aqueous solution. The hydrotropic micelles containing hydrotroperich cores exhibited not only high loading capacity of paclitaxel but also enhanced physical stability in aqueous media. Polyglycerol dendrimers increased the water solubility of paclitaxel by several orders of magnitude due to the presence of a high local density of ethylene glycol units having the hydrotropic property. The hydrogel nanoparticles were also prepared by simple mixing of two polymer solutions.

AB - Nanoparticulates, composed of hydrotropic polymers, dentrimers, or polymer complexes, were developed to deliver poorly water-soluble drugs. Nanoparticulate polymer systems were also developed for encapsulation of proteins. Hydrotropic amphiphilic block copolymers self-associated to form nanosized micelles in an aqueous solution. The hydrotropic micelles containing hydrotroperich cores exhibited not only high loading capacity of paclitaxel but also enhanced physical stability in aqueous media. Polyglycerol dendrimers increased the water solubility of paclitaxel by several orders of magnitude due to the presence of a high local density of ethylene glycol units having the hydrotropic property. The hydrogel nanoparticles were also prepared by simple mixing of two polymer solutions.

KW - Dendrimer

KW - Hydrogel

KW - Hydrotropic copolymer

KW - Polymer micelle

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M3 - Conference contribution

AN - SCOPUS:32044432333

SN - 0976798506

T3 - 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

SP - 124

EP - 127

BT - 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

A2 - Laudon, M.

A2 - Romanowicz, B.

T2 - 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005

Y2 - 8 May 2005 through 12 May 2005

ER -

Park JH, Huh KM, Lee SC, Lee WK, Ooya T, Park K. Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes. In Laudon M, Romanowicz B, editors, 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings. 2005. p. 124-127. (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).

Nanoparticulate drug delivery systems based on hydrotropic polymers, dendrimers, and polymer complexes

Abstract

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Conference

Keywords

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