Nanoporous silicified phospholipids and application to controlled glycolic acid release

Sang Hwa Kang; Hye Sun Lee; Jiho Lee; Seongmin Jeong; Jinsub Choi; Sang Cheon Lee; Kyung Ja Kim; Jeong Ho Chang

doi:10.1007/s11671-008-9165-x

Nanoporous silicified phospholipids and application to controlled glycolic acid release

Sang Hwa Kang, Hye Sun Lee, Jiho Lee, Seongmin Jeong, Jinsub Choi, Sang Cheon Lee, Kyung Ja Kim, Jeong Ho Chang

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This work demonstrates the synthesis and characterization of novel nanoporous silicified phospholipid bilayers assembled inorganic powders. The materials are obtained by silicification process with silica precursor at the hydrophilic region of phospholipid bilayers. This process involves the co-assembly of a chemically active phospholipids bilayer within the ordered porosity of a silica matrix and holds promise as a novel application for controlled drug release or drug containers with a high level of specificity and throughput. The controlled release application of the synthesized materials was achieved to glycolic acid, and obtained a zero-order release pattern due to the nanoporosity.

Original language	English
Pages (from-to)	355-360
Number of pages	6
Journal	Nanoscale Research Letters
Volume	3
Issue number	10
DOIs	https://doi.org/10.1007/s11671-008-9165-x
Publication status	Published - Oct 2008

Bibliographical note

Funding Information:
Acknowledgments This work was supported by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea.

Keywords

Controlled release
Glycolic acid
Nanoporous
Phospholipids
Silicification
Sol-gel

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10.1007/s11671-008-9165-x

Cite this

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abstract = "This work demonstrates the synthesis and characterization of novel nanoporous silicified phospholipid bilayers assembled inorganic powders. The materials are obtained by silicification process with silica precursor at the hydrophilic region of phospholipid bilayers. This process involves the co-assembly of a chemically active phospholipids bilayer within the ordered porosity of a silica matrix and holds promise as a novel application for controlled drug release or drug containers with a high level of specificity and throughput. The controlled release application of the synthesized materials was achieved to glycolic acid, and obtained a zero-order release pattern due to the nanoporosity.",

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note = "Funding Information: Acknowledgments This work was supported by a grant from the Fundamental R\&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea.",

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AU - Kang, Sang Hwa

AU - Lee, Hye Sun

AU - Lee, Jiho

AU - Jeong, Seongmin

AU - Choi, Jinsub

AU - Lee, Sang Cheon

AU - Kim, Kyung Ja

AU - Chang, Jeong Ho

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N2 - This work demonstrates the synthesis and characterization of novel nanoporous silicified phospholipid bilayers assembled inorganic powders. The materials are obtained by silicification process with silica precursor at the hydrophilic region of phospholipid bilayers. This process involves the co-assembly of a chemically active phospholipids bilayer within the ordered porosity of a silica matrix and holds promise as a novel application for controlled drug release or drug containers with a high level of specificity and throughput. The controlled release application of the synthesized materials was achieved to glycolic acid, and obtained a zero-order release pattern due to the nanoporosity.

AB - This work demonstrates the synthesis and characterization of novel nanoporous silicified phospholipid bilayers assembled inorganic powders. The materials are obtained by silicification process with silica precursor at the hydrophilic region of phospholipid bilayers. This process involves the co-assembly of a chemically active phospholipids bilayer within the ordered porosity of a silica matrix and holds promise as a novel application for controlled drug release or drug containers with a high level of specificity and throughput. The controlled release application of the synthesized materials was achieved to glycolic acid, and obtained a zero-order release pattern due to the nanoporosity.

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Nanoporous silicified phospholipids and application to controlled glycolic acid release

Abstract

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Keywords

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