Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes

Kwan Joong Kim, Young Sung Jung, Dong Min You, Seung Hyun Lee, Guemsan Lee, Kang Beom Kwon, Dae Ok Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Rhodiola rosea L. rhizome has been used as a traditional medicine to treat fatigue, depression, and cognitive dysfunction. We aimed to authenticate R. rosea L. rhizome using the DNA barcoding technique and to quantify its main compounds, total phenolics, total flavonoids, and antioxidant capacity, and then to investigate their neuroprotective effects. The sequences of internal transcribed spacer and trnH-psbA of R. rosea L. rhizomes showed a 99% identity with those of NCBI GenBank database according to BLAST searches. Analysis using reversed-phase HPLC revealed five main compounds in R. rosea L. rhizome. Rhodiola rosea L. rhizome and two bioactive compounds, salidroside and tyrosol, showed free radical scavenging activity. Rhodiola rosea L. rhizome and its identified compounds protected neuronal PC-12 cells against oxidative stress and showed moderate acetylcholinesterase inhibition. Taken together, these results suggest that R. rosea L. rhizomes with bioactives can be used as a functional ingredient with potential for neuroprotection. Graphic abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalFood Science and Biotechnology
Issue number2
Publication statusPublished - Feb 2021


  • Acetylcholinesterase
  • DNA barcoding
  • Oxidative stress
  • Salidroside
  • Tyrosol


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