Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords

Kyung Hee Lee; Do Heum Yoon; Myung Ae Chung; Jin Hun Sohn; Hye Jung Lee; Bae Hwan Lee

doi:10.1016/j.neures.2010.01.004

Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords

Kyung Hee Lee
, Do Heum Yoon
, Myung Ae Chung
, Jin Hun Sohn
, Hye Jung Lee
, Bae Hwan Lee

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

This study was conducted to whether the administration of mexiletine, a Na⁺ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment. Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination.

Original language	English
Pages (from-to)	59-64
Number of pages	6
Journal	Neuroscience Research
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/j.neures.2010.01.004
Publication status	Published - May 2010

Bibliographical note

Funding Information:
This work was financially supported by KICOS & MEST of Korea via the Global Partnership Program (GPP) and Basic Science Research Program of the National Research Foundation (NRF) funded by the Ministry of Education, Science, and Technology (R11-2005-014).

Keywords

Demyelination
Gliotoxin
Mexiletine
Motor evoked potentials
Rat
Spinal cord

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10.1016/j.neures.2010.01.004

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title = "Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords",

abstract = "This study was conducted to whether the administration of mexiletine, a Na+ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1\% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment. Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination.",

keywords = "Demyelination, Gliotoxin, Mexiletine, Motor evoked potentials, Rat, Spinal cord",

author = "Lee, \{Kyung Hee\} and Yoon, \{Do Heum\} and Chung, \{Myung Ae\} and Sohn, \{Jin Hun\} and Lee, \{Hye Jung\} and Lee, \{Bae Hwan\}",

note = "Funding Information: This work was financially supported by KICOS \& MEST of Korea via the Global Partnership Program (GPP) and Basic Science Research Program of the National Research Foundation (NRF) funded by the Ministry of Education, Science, and Technology (R11-2005-014).",

year = "2010",

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doi = "10.1016/j.neures.2010.01.004",

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volume = "67",

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AU - Lee, Kyung Hee

AU - Yoon, Do Heum

AU - Chung, Myung Ae

AU - Sohn, Jin Hun

AU - Lee, Hye Jung

AU - Lee, Bae Hwan

N1 - Funding Information: This work was financially supported by KICOS & MEST of Korea via the Global Partnership Program (GPP) and Basic Science Research Program of the National Research Foundation (NRF) funded by the Ministry of Education, Science, and Technology (R11-2005-014).

PY - 2010/5

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N2 - This study was conducted to whether the administration of mexiletine, a Na+ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment. Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination.

AB - This study was conducted to whether the administration of mexiletine, a Na+ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment. Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination.

KW - Demyelination

KW - Gliotoxin

KW - Mexiletine

KW - Motor evoked potentials

KW - Rat

KW - Spinal cord

UR - https://www.scopus.com/pages/publications/77952885307

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DO - 10.1016/j.neures.2010.01.004

M3 - Article

C2 - 20096736

AN - SCOPUS:77952885307

SN - 0168-0102

VL - 67

SP - 59

EP - 64

JO - Neuroscience Research

JF - Neuroscience Research

IS - 1

ER -

Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords

Abstract

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Keywords

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