New cytotoxic polyacetylenes from the marine sponge Petrosia

Young Ja Lim; Jung Sun Kim; Kwang Sik Im; Jee H. Jung; Chong O. Lee; Jongki Hong; Dong Kyoo Kim

doi:10.1021/np9900371

New cytotoxic polyacetylenes from the marine sponge Petrosia

Young Ja Lim, Jung Sun Kim, Kwang Sik Im, Jee H. Jung, Chong O. Lee, Jongki Hong, Dong Kyoo Kim

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

New polyacetylenic alcohols with a C₄₅ carbon skeleton (2) and with an enone moiety in the alkyl chain (C₄₆, 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.

Original language	English
Pages (from-to)	1215-1217
Number of pages	3
Journal	Journal of Natural Products
Volume	62
Issue number	9
DOIs	https://doi.org/10.1021/np9900371
Publication status	Published - Sept 1999

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10.1021/np9900371

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title = "New cytotoxic polyacetylenes from the marine sponge Petrosia",

abstract = "New polyacetylenic alcohols with a C45 carbon skeleton (2) and with an enone moiety in the alkyl chain (C46, 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.",

author = "Lim, {Young Ja} and Kim, {Jung Sun} and Im, {Kwang Sik} and Jung, {Jee H.} and Lee, {Chong O.} and Jongki Hong and Kim, {Dong Kyoo}",

year = "1999",

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doi = "10.1021/np9900371",

language = "English",

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pages = "1215--1217",

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T1 - New cytotoxic polyacetylenes from the marine sponge Petrosia

AU - Lim, Young Ja

AU - Kim, Jung Sun

AU - Im, Kwang Sik

AU - Jung, Jee H.

AU - Lee, Chong O.

AU - Hong, Jongki

AU - Kim, Dong Kyoo

PY - 1999/9

Y1 - 1999/9

N2 - New polyacetylenic alcohols with a C45 carbon skeleton (2) and with an enone moiety in the alkyl chain (C46, 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.

AB - New polyacetylenic alcohols with a C45 carbon skeleton (2) and with an enone moiety in the alkyl chain (C46, 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

New cytotoxic polyacetylenes from the marine sponge Petrosia

Abstract

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