On-chip erythrocyte deformability test under optical pressure

Won Gu Lee; Hyunwoo Bang; Hoyoung Yun; Joonmo Lee; Junha Park; Jung Kyung Kim; Seok Chung; Keunchang Cho; Chanil Chung; Dong Chul Han; Jun Keun Chang

doi:10.1039/b614912j

On-chip erythrocyte deformability test under optical pressure

Won Gu Lee, Hyunwoo Bang, Hoyoung Yun, Joonmo Lee, Junha Park, Jung Kyung Kim, Seok Chung, Keunchang Cho, Chanil Chung, Dong Chul Han, Jun Keun Chang

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect to the detection of cancerous diseases. To demonstrate the performance and sensitivity of the combined method, we introduce the concept of transit velocity, a modified elongation index, and shape recovery time of individual erythrocytes in a strictly confined region (2 μm deep, 4 μm wide, and 100 μm long). Finally, we investigate a synergy or convergence effect due to the combination of these parameters for in situ detection of cancerous diseases under optical pressure.

Original language	English
Pages (from-to)	516-519
Number of pages	4
Journal	Lab on a Chip
Volume	7
Issue number	4
DOIs	https://doi.org/10.1039/b614912j
Publication status	Published - 2007

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10.1039/b614912j

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title = "On-chip erythrocyte deformability test under optical pressure",

abstract = "This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect to the detection of cancerous diseases. To demonstrate the performance and sensitivity of the combined method, we introduce the concept of transit velocity, a modified elongation index, and shape recovery time of individual erythrocytes in a strictly confined region (2 μm deep, 4 μm wide, and 100 μm long). Finally, we investigate a synergy or convergence effect due to the combination of these parameters for in situ detection of cancerous diseases under optical pressure.",

author = "Lee, {Won Gu} and Hyunwoo Bang and Hoyoung Yun and Joonmo Lee and Junha Park and Kim, {Jung Kyung} and Seok Chung and Keunchang Cho and Chanil Chung and Han, {Dong Chul} and Chang, {Jun Keun}",

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T1 - On-chip erythrocyte deformability test under optical pressure

AU - Lee, Won Gu

AU - Bang, Hyunwoo

AU - Yun, Hoyoung

AU - Lee, Joonmo

AU - Park, Junha

AU - Kim, Jung Kyung

AU - Chung, Seok

AU - Cho, Keunchang

AU - Chung, Chanil

AU - Han, Dong Chul

AU - Chang, Jun Keun

PY - 2007

Y1 - 2007

N2 - This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect to the detection of cancerous diseases. To demonstrate the performance and sensitivity of the combined method, we introduce the concept of transit velocity, a modified elongation index, and shape recovery time of individual erythrocytes in a strictly confined region (2 μm deep, 4 μm wide, and 100 μm long). Finally, we investigate a synergy or convergence effect due to the combination of these parameters for in situ detection of cancerous diseases under optical pressure.

AB - This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect to the detection of cancerous diseases. To demonstrate the performance and sensitivity of the combined method, we introduce the concept of transit velocity, a modified elongation index, and shape recovery time of individual erythrocytes in a strictly confined region (2 μm deep, 4 μm wide, and 100 μm long). Finally, we investigate a synergy or convergence effect due to the combination of these parameters for in situ detection of cancerous diseases under optical pressure.

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SN - 1473-0197

VL - 7

SP - 516

EP - 519

JO - Lab on a Chip

JF - Lab on a Chip

IS - 4

ER -

On-chip erythrocyte deformability test under optical pressure

Abstract

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