TY - JOUR
T1 - Optimization of NADES-based green extraction of ellagitannins from rambutan peel with enhanced antioxidant activity
AU - Nam, Youn Hee
AU - Ahn, Soo Mi
AU - Seo, Gyeong Jin
AU - Kim, Na Woo
AU - Shin, Sung Woo
AU - Nuankaew, Wanlapa
AU - Murughanantham, Nevedita
AU - Pandian, Subha
AU - Hwang, Jae Sung
AU - Hong, Bin Na
AU - Kang, Tong Ho
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/5/30
Y1 - 2025/5/30
N2 - Rambutan (Nephelium lappaceum L.) peel contains bioactive compounds such as geraniin, corilagin, ellagic acid, and gallic acid, known for their antioxidant, anti-inflammatory, and anticancer properties. Traditional extraction methods involve toxic solvents like methanol and ethanol, posing environmental and safety concerns. This study optimized the extraction of ellagitannins from rambutan peel using Natural Deep Eutectic Solvents (NADES), which are sustainable, non-toxic, and cost-effective. The optimal conditions—water content (20 %), temperature (80 °C), and time (60 min)—were identified using Response Surface Methodology (RSM). The NADES system, composed of betaine (hydrogen bond acceptor) and 1,2-propanediol (donor) in a 1:2 M ratio, achieved the highest ellagitannin yield (54.29 μg/mg) and antioxidant activity (DPPH IC50 = 35.86 μg/mL, ABTS IC50 = 37.66 μg/mL). These findings demonstrate that NADES can be effectively tailored for bioactive compound extraction from rambutan peel, providing a greener alternative for the food, pharmaceutical, and cosmetic industries.
AB - Rambutan (Nephelium lappaceum L.) peel contains bioactive compounds such as geraniin, corilagin, ellagic acid, and gallic acid, known for their antioxidant, anti-inflammatory, and anticancer properties. Traditional extraction methods involve toxic solvents like methanol and ethanol, posing environmental and safety concerns. This study optimized the extraction of ellagitannins from rambutan peel using Natural Deep Eutectic Solvents (NADES), which are sustainable, non-toxic, and cost-effective. The optimal conditions—water content (20 %), temperature (80 °C), and time (60 min)—were identified using Response Surface Methodology (RSM). The NADES system, composed of betaine (hydrogen bond acceptor) and 1,2-propanediol (donor) in a 1:2 M ratio, achieved the highest ellagitannin yield (54.29 μg/mg) and antioxidant activity (DPPH IC50 = 35.86 μg/mL, ABTS IC50 = 37.66 μg/mL). These findings demonstrate that NADES can be effectively tailored for bioactive compound extraction from rambutan peel, providing a greener alternative for the food, pharmaceutical, and cosmetic industries.
KW - Antioxidant activity
KW - Central composite design
KW - Ellagitannins
KW - Natural deep eutectic solvents
KW - Rambutan peel
KW - Response surface methodology
UR - http://www.scopus.com/inward/record.url?scp=85217682710&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2025.143308
DO - 10.1016/j.foodchem.2025.143308
M3 - Article
C2 - 39952176
AN - SCOPUS:85217682710
SN - 0308-8146
VL - 475
JO - Food Chemistry
JF - Food Chemistry
M1 - 143308
ER -