TY - JOUR
T1 - Osteoblast-Osteoclast Communication and Bone Homeostasis
AU - Kim, Jung Min
AU - Lin, Chujiao
AU - Stavre, Zheni
AU - Greenblatt, Matthew B.
AU - Shim, Jae Hyuck
PY - 2020/9/10
Y1 - 2020/9/10
N2 - Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direct interaction between osteoblasts and osteoclasts allows bidirectional transduction of activation signals through EFNB2-EPHB4, FASL-FAS or SEMA3A-NRP1, regulating differentiation and survival of osteoblasts or osteoclasts. Alternatively, osteoblasts produce a range of different secretory molecules, including M-CSF, RANKL/OPG, WNT5A, and WNT16, that promote or suppress osteoclast differentiation and development. Osteoclasts also influence osteoblast formation and differentiation through secretion of soluble factors, including S1P, SEMA4D, CTHRC1 and C3. Here we review the current knowledge regarding membrane bound- and soluble factors governing cross-talk between osteoblasts and osteoclasts.
AB - Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direct interaction between osteoblasts and osteoclasts allows bidirectional transduction of activation signals through EFNB2-EPHB4, FASL-FAS or SEMA3A-NRP1, regulating differentiation and survival of osteoblasts or osteoclasts. Alternatively, osteoblasts produce a range of different secretory molecules, including M-CSF, RANKL/OPG, WNT5A, and WNT16, that promote or suppress osteoclast differentiation and development. Osteoclasts also influence osteoblast formation and differentiation through secretion of soluble factors, including S1P, SEMA4D, CTHRC1 and C3. Here we review the current knowledge regarding membrane bound- and soluble factors governing cross-talk between osteoblasts and osteoclasts.
KW - bone
KW - bone remodeling
KW - osteoblast
KW - osteoclast
UR - http://www.scopus.com/inward/record.url?scp=85091052072&partnerID=8YFLogxK
U2 - 10.3390/cells9092073
DO - 10.3390/cells9092073
M3 - Review article
C2 - 32927921
AN - SCOPUS:85091052072
SN - 2073-4409
VL - 9
JO - Cells
JF - Cells
IS - 9
M1 - 2075
ER -