Abstract
Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have a paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve as signaling agents that enhance cancer cell proliferation, migration, and resistance to drugs. However, at elevated levels, ROS induce oxidative stress, causing damage to biomolecules and leading to cell death. Cancer cells have developed mechanisms to manage ROS levels, including activating pathways such as NRF2, NF-κB, and PI3K/Akt. This review explores the relationship between ROS and cancer, focusing on cell death mechanisms like apoptosis, ferroptosis, and autophagy, highlighting the potential therapeutic strategies that exploit ROS to target cancer cells.
Original language | English |
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Article number | 12387 |
Journal | International Journal of Molecular Sciences |
Volume | 25 |
Issue number | 22 |
DOIs | |
Publication status | Published - Nov 2024 |
Bibliographical note
Publisher Copyright:© 2024 by the authors.
Keywords
- cancer
- oxidative stress
- reactive oxygen species (ROS)
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Studies from Kyung Hee University in the Area of Cancer Published (Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species)
Ha, J., Kim, S. S., Kang, I., Choe, W., Yeo, S.-G. & Kim, S. J.
2/12/24
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