Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species

Songhyun Ju, Manish Kumar Singh, Sunhee Han, Jyotsna Ranbhise, Joohun Ha, Wonchae Choe, Kyung Sik Yoon, Seung Geun Yeo, Sung Soo Kim, Insug Kang

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have a paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve as signaling agents that enhance cancer cell proliferation, migration, and resistance to drugs. However, at elevated levels, ROS induce oxidative stress, causing damage to biomolecules and leading to cell death. Cancer cells have developed mechanisms to manage ROS levels, including activating pathways such as NRF2, NF-κB, and PI3K/Akt. This review explores the relationship between ROS and cancer, focusing on cell death mechanisms like apoptosis, ferroptosis, and autophagy, highlighting the potential therapeutic strategies that exploit ROS to target cancer cells.

Original languageEnglish
Article number12387
JournalInternational Journal of Molecular Sciences
Volume25
Issue number22
DOIs
Publication statusPublished - Nov 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Keywords

  • cancer
  • oxidative stress
  • reactive oxygen species (ROS)

Fingerprint

Dive into the research topics of 'Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species'. Together they form a unique fingerprint.

Cite this