Oxygenated hexylitaconates from a marine sponge-derived fungus Penicillium sp.

Jian Lin Li, Ping Zhang, Yoon Mi Lee, Jongki Hong, Eun Sook Yoo, Kyung Sook Bae, Jee H. Jung

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

In the course of our search for bioactive metabolites from marine organisms, new hexylitaconic acid derivatives (1-4), along with (3S)-hexylitaconic acid (5), were isolated from a sponge-derived fungus Penicillium sp. Based on the NMR and MS data, the structures of compounds 1-4 were defined as α,β-dicarboxylic acid derivatives, such as hexylitaconic acid and tensyuic acids which were previously reported as metabolite of Aspergillus niger, Penicillium striatisporum, or Apiospora montagnei. The isolated compounds were evaluated for cytotoxicity against a panel of five human solid tumor cell lines, and for anti-inflammatory activity gauged by their inhibitory effects on the production of major pro-inflammatory mediators (nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β) in murine macrophage cells. Compounds 1 and 4 showed weak inhibition of IL-1β production at the concentration of 200 μM.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Anti-inflammatory
  • Cytotoxicity
  • Dicarboxylic acid
  • Hexylitaconate
  • Penicillium sp.
  • Sponge-derived fungus

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