TY - GEN
T1 - Pancreatic beta-cell-laden contact lens based on tetra-PEG for diabetes treatment
AU - Heo, Y. J.
AU - Iwanaga, S.
AU - Takeuchi, S.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - We present contact-lens-shaped, pancreatic beta-cells-laden tetra-polyethylene glycol (PEG) gel scaffolds that can secrete insulin in response to glucose concentration. Eye-wearable cell-laden scaffold, "cell contact lens," can be a promising approach for non-invasive cell-based therapy. To encapsulate cells, we employed tetra-PEG gel due to its high mechanical strength and good graft survival. By a simple molding process, we fabricated the cell contact lens with ∼12 mm diameter and ∼1 mm height, containing pancreatic beta-cells with extracellular matrix proteins. We also verified that the encapsulated cells could secrete insulin responding to glucose concentration in vitro, thus showing feasible applications for diabetes treatment.
AB - We present contact-lens-shaped, pancreatic beta-cells-laden tetra-polyethylene glycol (PEG) gel scaffolds that can secrete insulin in response to glucose concentration. Eye-wearable cell-laden scaffold, "cell contact lens," can be a promising approach for non-invasive cell-based therapy. To encapsulate cells, we employed tetra-PEG gel due to its high mechanical strength and good graft survival. By a simple molding process, we fabricated the cell contact lens with ∼12 mm diameter and ∼1 mm height, containing pancreatic beta-cells with extracellular matrix proteins. We also verified that the encapsulated cells could secrete insulin responding to glucose concentration in vitro, thus showing feasible applications for diabetes treatment.
KW - Contact lens
KW - Diabetes mellitus
KW - Hydrogel molding
KW - Pancreatic beta cells
KW - Tetra-PEG gel
UR - http://www.scopus.com/inward/record.url?scp=84907313604&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84907313604
SN - 9781632666246
T3 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
SP - 1182
EP - 1184
BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PB - Chemical and Biological Microsystems Society
T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Y2 - 27 October 2013 through 31 October 2013
ER -
