TY - JOUR
T1 - Pattern of cerebral hypoperfusion in Alzheimer's disease and mild cognitive impairment measured with arterial spin-labeling MR imaging
T2 - Initial experience
AU - Johnson, Nathan A.
AU - Jahng, Geon Ho
AU - Weiner, Michael W.
AU - Miller, Bruce L.
AU - Chui, Helena C.
AU - Jagust, William J.
AU - Gorno-Tempini, Maria L.
AU - Schuff, Norbert
N1 - Funding Information:
Supported in part by a research applications grant of the Department of Veterans Affairs REAP. M.W.W. supported by NIH grant AG10897. H.C.C. supported by NIH grant AG12435.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/6
Y1 - 2006/6
N2 - Purpose: To prospectively determine if pulsed arterial spin-labeling perfusion magnetic resonance (MR) imaging depicts regional cerebral hypoperfusion in subjects with Alzheimer's disease (AD) and mild cognitive impairment (MCI), compared with perfusion in cognitively normal (CN) subjects, that is consistent with results of fluorodeoxyglucose (FDG) positron emission tomography (PET) and hexamethylpropyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) studies of similar populations. Materials and methods: Institutional review board approval and informed consent were obtained. 20 subjects with AD (13 men, 7 women; mean age = 72.9 years), 18 with MCI (9 men, 9 women; mean age = 73.3 years), and 23 CN subjects (10 men, 13 women; mean age = 72.9 years) underwent arterial spin-labeling and volumetric T1-weighted structural MR imaging. Perfusion images were coregistered to structural images, corrected for partial volume effects (PVEs) with information from the structural image to determine tissue content of perfusion voxels, and normalized to a study-specific template. Analyses of perfusion differences between groups, with and without corrections for PVEs, were performed on a voxel-by-voxel basis with a one-tailed fixed-effects analysis of covariance model adjusted for age. In addition, tests were performed with and without accounting for global perfusion. Results: The AD group showed significant regional hypoperfusion, compared with the CN group, in the right inferior parietal cortex extending into the bilateral posterior cingulate gyri (P < 0.001), bilateral superior and middle frontal gyri (P < 0.001), and left inferior parietal lobe (P = 0.007). When PVEs from underlying cortical gray matter atrophy were accounted for, the AD group still showed hypoperfusion in the right inferior parietal lobe extending into the bilateral posterior cingulate gyri (P < 0.001) and left (P = 0.003) and right (P = 0.012) middle frontal gyri. With a more liberal voxel-level threshold of P < 0.01, the MCI group showed significant regional hypoperfusion relative to the CN group in the inferior right parietal lobe (P = 0.046), similar to the region of greatest significance in the AD group. Conclusion: Arterial spin-labeling MR imaging showed regional hypoperfusion with AD, in brain regions similar to those seen in FDG PET and HMPAO SPECT studies of similar populations; this hypoperfusion persists after accounting for underlying cortical gray matter atrophy.
AB - Purpose: To prospectively determine if pulsed arterial spin-labeling perfusion magnetic resonance (MR) imaging depicts regional cerebral hypoperfusion in subjects with Alzheimer's disease (AD) and mild cognitive impairment (MCI), compared with perfusion in cognitively normal (CN) subjects, that is consistent with results of fluorodeoxyglucose (FDG) positron emission tomography (PET) and hexamethylpropyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) studies of similar populations. Materials and methods: Institutional review board approval and informed consent were obtained. 20 subjects with AD (13 men, 7 women; mean age = 72.9 years), 18 with MCI (9 men, 9 women; mean age = 73.3 years), and 23 CN subjects (10 men, 13 women; mean age = 72.9 years) underwent arterial spin-labeling and volumetric T1-weighted structural MR imaging. Perfusion images were coregistered to structural images, corrected for partial volume effects (PVEs) with information from the structural image to determine tissue content of perfusion voxels, and normalized to a study-specific template. Analyses of perfusion differences between groups, with and without corrections for PVEs, were performed on a voxel-by-voxel basis with a one-tailed fixed-effects analysis of covariance model adjusted for age. In addition, tests were performed with and without accounting for global perfusion. Results: The AD group showed significant regional hypoperfusion, compared with the CN group, in the right inferior parietal cortex extending into the bilateral posterior cingulate gyri (P < 0.001), bilateral superior and middle frontal gyri (P < 0.001), and left inferior parietal lobe (P = 0.007). When PVEs from underlying cortical gray matter atrophy were accounted for, the AD group still showed hypoperfusion in the right inferior parietal lobe extending into the bilateral posterior cingulate gyri (P < 0.001) and left (P = 0.003) and right (P = 0.012) middle frontal gyri. With a more liberal voxel-level threshold of P < 0.01, the MCI group showed significant regional hypoperfusion relative to the CN group in the inferior right parietal lobe (P = 0.046), similar to the region of greatest significance in the AD group. Conclusion: Arterial spin-labeling MR imaging showed regional hypoperfusion with AD, in brain regions similar to those seen in FDG PET and HMPAO SPECT studies of similar populations; this hypoperfusion persists after accounting for underlying cortical gray matter atrophy.
UR - http://www.scopus.com/inward/record.url?scp=33744920578&partnerID=8YFLogxK
U2 - 10.1016/j.ics.2006.04.009
DO - 10.1016/j.ics.2006.04.009
M3 - Article
AN - SCOPUS:33744920578
SN - 0531-5131
VL - 1290
SP - 108
EP - 122
JO - International Congress Series
JF - International Congress Series
ER -