TY - GEN
T1 - PEG bonded fluorescent-hydrogel fibers with less inflammation for long-term subcutaneous glucose monitoring
AU - Heo, Y. J.
AU - Takahashi, M.
AU - Shibata, H.
AU - Okitsu, T.
AU - Kawanishi, T.
AU - Takeuchi, S.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2011
Y1 - 2011
N2 - We present polyethylene glycol (PEG) bonded poly-acrylamide (PAM) hydrogel fibers with glucose-responsive monomer to monitor blood glucose concentration in vivo for over 4 months. To realize long-term subcutaneous glucose monitoring, we employed fiber-structure and PEG-bonded PAM hydrogel. The fiber-shaped sensors can be injected to subcutaneous tissues, remain in an implantation site and be easily removed after use. PEG can enhance biocompatibility, resulting in maintaining the functionality of implanted sensors in vivo for a long-period. The implanted PEG-bonded PAM fibers showed less inflammation, glowed through the skin and continuously responded to blood glucose concentration, thereby promising practical, long-term subcutaneous glucose monitoring.
AB - We present polyethylene glycol (PEG) bonded poly-acrylamide (PAM) hydrogel fibers with glucose-responsive monomer to monitor blood glucose concentration in vivo for over 4 months. To realize long-term subcutaneous glucose monitoring, we employed fiber-structure and PEG-bonded PAM hydrogel. The fiber-shaped sensors can be injected to subcutaneous tissues, remain in an implantation site and be easily removed after use. PEG can enhance biocompatibility, resulting in maintaining the functionality of implanted sensors in vivo for a long-period. The implanted PEG-bonded PAM fibers showed less inflammation, glowed through the skin and continuously responded to blood glucose concentration, thereby promising practical, long-term subcutaneous glucose monitoring.
KW - Biocompatible interface
KW - Glucose-responsive fluorescence
KW - Long-term in vivo glucose monitoring
KW - Transdermal detection
UR - http://www.scopus.com/inward/record.url?scp=84883826237&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883826237
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 1879
EP - 1881
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -