PEGylation of a shell over core-shell MOFs—a novel strategy for preventing agglomeration and synergism in terms of physicochemical and biological properties

Nisha G. Pillai, K. Archana, Kyong Yop Rhee, A. Asif

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We demonstrate a new strategy of PEGylation over core-shell MOFs of HKUST-1 and Cu-MOF-2 by a solvothermal method. The novel synthesized PEGylated core-shell MOFs has synergistic enhancement in terms of physicochemical and biological properties. FTIR spectroscopy and XRD analysis described the bonding characteristics of the double-shelled-core MOFs PEG@HKUST-1@CuMOF-2 and PEG@CuMOF-2@HKUST-1. XPS and EDAX spectroscopy confirmed the structural features of the PEG@core-shell MOFs. The as-synthesized PEG-modified core-shell MOFs showed a readily identifiable morphology with a reduction in particle size. The significant observation from SEM and TEM was that agglomeration disappeared completely, and the morphology of individual core-shell MOFs was clearly revealed. BET analysis provided the surface characteristics of MOF compounds. The chemical states of frameworks were established by XPS. The designed PEG-modified copper MOFs were evaluated for their activity against Gram-positive (Staphylococcus aureus, Enterococcus faecalis), Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacterial species and activity against fungal species (Aspergillus niger and Candida albicans). This research work highlights a facile and synergistic approach to design promising biocompatible nano-dimensional core-shell MOFs for biological applications.

Original languageEnglish
Pages (from-to)10665-10677
Number of pages13
JournalJournal of Materials Chemistry B
Volume11
Issue number44
DOIs
Publication statusPublished - 16 Oct 2023

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© 2023 The Royal Society of Chemistry.

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