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Performance analysis of extinction-based localized surface plasmon resonance biosensors in the presence of surface roughness

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

We investigated the effect of rough surface on the performance of extinction-based localized surface plasmon resonance (LSPR) biosensors. The sensor measures resonance wavelength shifts in transmittance due to biomolecular interactions amplified by periodic nanostructures. The numerical calculation was conducted using rigorous coupled-wave analysis with Gaussian random profiles. The results suggest that, when a surface has a roughness smaller than 2 nm, the sensitivity of an LSPR biosensor is not significantly affected regardless of correlation length (CL). However, we found that extinction peak amplitude and curve width are affected substantially with a decrease in CL. At CL less than 100 nm, surface roughness may induce interference between localized surface plasmons excited by the surface and nanowires, which can lead to significant degradation of sensor performance.

Original languageEnglish
Title of host publicationPlasmonics in Biology and Medicine VI
DOIs
Publication statusPublished - 2009
EventPlasmonics in Biology and Medicine VI - San Jose, CA, United States
Duration: 26 Jan 200927 Jan 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7192
ISSN (Print)1605-7422

Conference

ConferencePlasmonics in Biology and Medicine VI
Country/TerritoryUnited States
CitySan Jose, CA
Period26/01/0927/01/09

Keywords

  • Metallic nanowires
  • Sensitivity enhancement
  • Surface plasmon resonance
  • Surface roughness

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