pH-Responsive mineralized nanoparticles for bacteria-triggered topical release of antibiotics

Kyung Hyun Min; Eun Young Jang; Hong Jae Lee; Yu Shik Hwang; Jae In Ryu; Ji Hoi Moon; Sang Cheon Lee

doi:10.1016/j.jiec.2018.11.027

pH-Responsive mineralized nanoparticles for bacteria-triggered topical release of antibiotics

Kyung Hyun Min, Eun Young Jang, Hong Jae Lee, Yu Shik Hwang, Jae In Ryu, Ji Hoi Moon, Sang Cheon Lee

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We report on doxycycline (DOXY)-loaded calcium carbonate (CaCO₃) mineralized nanoparticles (DOXY-MNPs) that can induce selective topical release of antibiotics to target oral plaque biofilms with acidic pH (ca. 4.5–5.5). The DOXY-MNPs were fabricated through a block copolymer-templated mineralization approach with simultaneous loading of an antibacterial drug, DOXY. The CaCO₃ mineral core of DOXY-MNPs inhibited the leakage of entrapped DOXY in environments with normal salivary pH. However, in acidic pH, the DOXY release was triggered by the dissolution of CaCO₃ mineral cores. The DOXY-MNPs showed effective antibacterial therapeutic activity to Prevotella intermedia bacterial cells with a potent treatment of biofilms.

Original language	English
Pages (from-to)	210-219
Number of pages	10
Journal	Journal of Industrial and Engineering Chemistry
Volume	71
DOIs	https://doi.org/10.1016/j.jiec.2018.11.027
Publication status	Published - 25 Mar 2019

Bibliographical note

Publisher Copyright:
© 2018 The Korean Society of Industrial and Engineering Chemistry

Keywords

Bacteria-triggered
Calcium carbonate
Doxycycline
Topical delivery
pH-responsive

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10.1016/j.jiec.2018.11.027

Cite this

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title = "pH-Responsive mineralized nanoparticles for bacteria-triggered topical release of antibiotics",

abstract = "We report on doxycycline (DOXY)-loaded calcium carbonate (CaCO3) mineralized nanoparticles (DOXY-MNPs) that can induce selective topical release of antibiotics to target oral plaque biofilms with acidic pH (ca. 4.5–5.5). The DOXY-MNPs were fabricated through a block copolymer-templated mineralization approach with simultaneous loading of an antibacterial drug, DOXY. The CaCO3 mineral core of DOXY-MNPs inhibited the leakage of entrapped DOXY in environments with normal salivary pH. However, in acidic pH, the DOXY release was triggered by the dissolution of CaCO3 mineral cores. The DOXY-MNPs showed effective antibacterial therapeutic activity to Prevotella intermedia bacterial cells with a potent treatment of biofilms.",

keywords = "Bacteria-triggered, Calcium carbonate, Doxycycline, Topical delivery, pH-responsive",

author = "Min, {Kyung Hyun} and Jang, {Eun Young} and Lee, {Hong Jae} and Hwang, {Yu Shik} and Ryu, {Jae In} and Moon, {Ji Hoi} and Lee, {Sang Cheon}",

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doi = "10.1016/j.jiec.2018.11.027",

language = "English",

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T1 - pH-Responsive mineralized nanoparticles for bacteria-triggered topical release of antibiotics

AU - Min, Kyung Hyun

AU - Jang, Eun Young

AU - Lee, Hong Jae

AU - Hwang, Yu Shik

AU - Ryu, Jae In

AU - Moon, Ji Hoi

AU - Lee, Sang Cheon

PY - 2019/3/25

Y1 - 2019/3/25

N2 - We report on doxycycline (DOXY)-loaded calcium carbonate (CaCO3) mineralized nanoparticles (DOXY-MNPs) that can induce selective topical release of antibiotics to target oral plaque biofilms with acidic pH (ca. 4.5–5.5). The DOXY-MNPs were fabricated through a block copolymer-templated mineralization approach with simultaneous loading of an antibacterial drug, DOXY. The CaCO3 mineral core of DOXY-MNPs inhibited the leakage of entrapped DOXY in environments with normal salivary pH. However, in acidic pH, the DOXY release was triggered by the dissolution of CaCO3 mineral cores. The DOXY-MNPs showed effective antibacterial therapeutic activity to Prevotella intermedia bacterial cells with a potent treatment of biofilms.

AB - We report on doxycycline (DOXY)-loaded calcium carbonate (CaCO3) mineralized nanoparticles (DOXY-MNPs) that can induce selective topical release of antibiotics to target oral plaque biofilms with acidic pH (ca. 4.5–5.5). The DOXY-MNPs were fabricated through a block copolymer-templated mineralization approach with simultaneous loading of an antibacterial drug, DOXY. The CaCO3 mineral core of DOXY-MNPs inhibited the leakage of entrapped DOXY in environments with normal salivary pH. However, in acidic pH, the DOXY release was triggered by the dissolution of CaCO3 mineral cores. The DOXY-MNPs showed effective antibacterial therapeutic activity to Prevotella intermedia bacterial cells with a potent treatment of biofilms.

KW - Bacteria-triggered

KW - Calcium carbonate

KW - Doxycycline

KW - Topical delivery

KW - pH-responsive

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DO - 10.1016/j.jiec.2018.11.027

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SN - 1226-086X

VL - 71

SP - 210

EP - 219

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

pH-Responsive mineralized nanoparticles for bacteria-triggered topical release of antibiotics

Abstract

Bibliographical note

Keywords

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