PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs

Hwa Pyeong Rim; Kyung Hyun Min; Hong Jae Lee; Seo Young Jeong; Sang Cheon Lee

doi:10.1002/anie.201101536

PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs

Hwa Pyeong Rim, Kyung Hyun Min, Hong Jae Lee, Seo Young Jeong, Sang Cheon Lee

Research output: Contribution to journal › Article › peer-review

238 Citations (Scopus)

Abstract

Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).

Original language	English
Pages (from-to)	8853-8857
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	38
DOIs	https://doi.org/10.1002/anie.201101536
Publication status	Published - 12 Sept 2011

Keywords

drug delivery
host-guest systems
mesoporous materials
mineralization
nanoparticles

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10.1002/anie.201101536

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abstract = "Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).",

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AU - Jeong, Seo Young

AU - Lee, Sang Cheon

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KW - host-guest systems

KW - mesoporous materials

KW - mineralization

KW - nanoparticles

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PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs

Abstract

Keywords

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