Abstract
On high performance liquid chromatography, the caffeoylquinic acid (CQ) occupying the highest proportion of the water-ethanol (7:3) extract of Aster glehni (Compositae) leaves was 3-Op- coumaroylquinic acid (46.10 ± 4.22 mg/g of dried weight) among CQs tested. The IC 50 of the water-ethanol (7:3) extract was 4.23 ± 0.24 μg/mL in the peroxynitrite (ONOO-)-scavenging assay. Phytochemical isolation from A. glehni extract yielded three kaempferol glycosides. The water-ethanol (7:3) extract and both p-coumaric acid and caffeic acid, phenylpropanoid moieties of CQs, had sedative effects in pentobarbital-induced sleeping time in mice and anticonvulsant effects in pentylenetetrazole-induced mice. Furthermore, the phenolic substance-rich W-E (7:3) extract of A. glehni could be used to treat anxiety or convulsion partly due to its peroxynitrite- scavenging mechanism.
| Original language | English |
|---|---|
| Pages (from-to) | 423-430 |
| Number of pages | 8 |
| Journal | Archives of Pharmacal Research |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2012 |
Bibliographical note
Funding Information:This work (Grants No. 2010C142201) was supported by Business for Cooperative R&D between Industry, Academy, and Research Institute funded by the Korea Small and Medium Business Administration in 2010.
Keywords
- Anticonvulsant
- Aster glehni
- Caffeoylquinic acid
- Compositae
- High performance liquid chromatography
- Peroxynitrite
- Sedative