Abstract
The role of advanced glycation end products (AGEs) is not limited to diabetes and diabetes-related complications. There are multiple modulators, including the receptor for advanced glycation end products, high mobility group box 1, glyoxalase 1, nuclear factor-kappa B, tumor necrosis factor-α, chronic unpredictable stress, reactive oxygen species, and inflammatory cytokines, which interact with AGE signaling and control diabetes, modulating these interacting modulators. The progression of diabetes, as well as related complications, can be controlled and treated. Natural products rich in bioactive constituents can interact with AGEs and their related mediators through various signaling cascades, thereby controlling and preventing the progression of diabetes. This review provides a deeper assessment of the signaling pathway, interactions between phytochemicals and AGEs, and its mediators, to develop a multifold therapeutic approach to prevent and treat diabetes and its related complications.
| Original language | English |
|---|---|
| Pages (from-to) | 378-401 |
| Number of pages | 24 |
| Journal | Archives of Pharmacal Research |
| Volume | 44 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2021 |
Bibliographical note
Publisher Copyright:© 2021, The Pharmaceutical Society of Korea.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Advanced glycation end products
- Coronary artery disease
- Diabetes
- Nitric oxide
- Phytochemicals
- Reactive oxygen species
- Receptor for advanced end product glycation
Fingerprint
Dive into the research topics of 'Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver