TY - JOUR
T1 - Polymorphism of nitric oxide synthase 1 affects the clinical phenotypes of ischemic stroke in Korean population
AU - Yoo, Seung Don
AU - Park, Jun Sang
AU - Yun, Dong Hwan
AU - Kim, Hee Sang
AU - Kim, Su Kang
AU - Kim, Dong Hwan
AU - Chon, Jinmann
AU - Je, Goun
AU - Kim, Yoon Seong
AU - Chung, Joo Ho
AU - Chung, Seung Joon
AU - Yeo, Jin Ah
N1 - Publisher Copyright:
©2016 by Korean Academy of Rehabilitation Medicine.
PY - 2016
Y1 - 2016
N2 - Objective To investigate whether four single nucleotide polymorphisms (SNPs) rs2293054 [Ile734Ile], rs1047735 [His902His], rs2293044 [Val1353Val], rs2682826 (3'UTR) of nitric oxide synthase 1 (NOS1) are associated with the development and clinical phenotypes of ischemic stroke. Methods We enrolled 120 ischemic stroke patients and 314 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of the National Institutes of Health Stroke Survey (NIHSS, <6 and >6) and Modified Barthel Index (MBI, <60 and >60). SNPStats, SNPAnalyzer, and HelixTree programs were used to calculate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. Multiple logistic regression models were performed to analyze genetic data. Results No SNPs of the NOS1 gene were found to be associated with ischemic stroke. However, in an analysis of clinical phenotypes, we found that rs2293054 was associated with the NIHSS scores of ischemic stroke patients in codominant (p=0.019), dominant (p=0.007), overdominant (p=0.033), and log-additive (p=0.0048) models. Also, rs2682826 revealed a significant association in the recessive model (p=0.034). In allele frequency analysis, we also found that the T alleles of rs2293054 were associated with lower NIHSS scores (p=0.007). Respectively, rs2293054 had a significant association in the MBI scores of ischemic stroke in codominant (p=0.038), dominant (p=0.031), overdominant (p=0.045), and log-additive (p=0.04) models. Conclusion These results suggest that NOS1 may be related to the clinical phenotypes of ischemic stroke in Korean population.
AB - Objective To investigate whether four single nucleotide polymorphisms (SNPs) rs2293054 [Ile734Ile], rs1047735 [His902His], rs2293044 [Val1353Val], rs2682826 (3'UTR) of nitric oxide synthase 1 (NOS1) are associated with the development and clinical phenotypes of ischemic stroke. Methods We enrolled 120 ischemic stroke patients and 314 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of the National Institutes of Health Stroke Survey (NIHSS, <6 and >6) and Modified Barthel Index (MBI, <60 and >60). SNPStats, SNPAnalyzer, and HelixTree programs were used to calculate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. Multiple logistic regression models were performed to analyze genetic data. Results No SNPs of the NOS1 gene were found to be associated with ischemic stroke. However, in an analysis of clinical phenotypes, we found that rs2293054 was associated with the NIHSS scores of ischemic stroke patients in codominant (p=0.019), dominant (p=0.007), overdominant (p=0.033), and log-additive (p=0.0048) models. Also, rs2682826 revealed a significant association in the recessive model (p=0.034). In allele frequency analysis, we also found that the T alleles of rs2293054 were associated with lower NIHSS scores (p=0.007). Respectively, rs2293054 had a significant association in the MBI scores of ischemic stroke in codominant (p=0.038), dominant (p=0.031), overdominant (p=0.045), and log-additive (p=0.04) models. Conclusion These results suggest that NOS1 may be related to the clinical phenotypes of ischemic stroke in Korean population.
KW - Ischemic stroke
KW - Modified barthel index
KW - National institutes of health stroke survey
KW - Nitric oxide synthase 1
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84959268902&partnerID=8YFLogxK
U2 - 10.5535/arm.2016.40.1.102
DO - 10.5535/arm.2016.40.1.102
M3 - Article
AN - SCOPUS:84959268902
SN - 2234-0645
VL - 40
SP - 102
EP - 110
JO - Annals of Rehabilitation Medicine
JF - Annals of Rehabilitation Medicine
IS - 1
ER -