PPAR-γ agonistic metabolites from the ascidian Herdmania momus

Jian Lin Li; Bin Xiao; Minhi Park; Eun Sook Yoo; Sook Shin; Jongki Hong; Hae Young Chung; Hyung Sik Kim; Jee H. Jung

doi:10.1021/np300401g

PPAR-γ agonistic metabolites from the ascidian Herdmania momus

Jian Lin Li, Bin Xiao, Minhi Park, Eun Sook Yoo, Sook Shin, Jongki Hong, Hae Young Chung, Hyung Sik Kim, Jee H. Jung

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Seven new amino acid derivatives (1-4 and 6-8) were isolated from MeOH extracts of the marine ascidian Herdmania momus. Planar structures were established on the basis of NMR, IR, and MS spectroscopic analyses. Absolute configurations of these compounds were derived from specific rotation and CD analysis. The peroxisome proliferator-activated receptor (PPAR)-γ agonistic activities of the compounds were investigated due to the similarity of the structural motif to that of the antidiabetic drug rosiglitazone. Analogues with indoleglyoxyl moieties (5, 6, and 8) showed significant PPAR-γ activation in Ac2F rat liver cells.

Original language	English
Pages (from-to)	2082-2087
Number of pages	6
Journal	Journal of Natural Products
Volume	75
Issue number	12
DOIs	https://doi.org/10.1021/np300401g
Publication status	Published - 28 Dec 2012

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abstract = "Seven new amino acid derivatives (1-4 and 6-8) were isolated from MeOH extracts of the marine ascidian Herdmania momus. Planar structures were established on the basis of NMR, IR, and MS spectroscopic analyses. Absolute configurations of these compounds were derived from specific rotation and CD analysis. The peroxisome proliferator-activated receptor (PPAR)-γ agonistic activities of the compounds were investigated due to the similarity of the structural motif to that of the antidiabetic drug rosiglitazone. Analogues with indoleglyoxyl moieties (5, 6, and 8) showed significant PPAR-γ activation in Ac2F rat liver cells.",

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AU - Li, Jian Lin

AU - Xiao, Bin

AU - Park, Minhi

AU - Yoo, Eun Sook

AU - Shin, Sook

AU - Hong, Jongki

AU - Chung, Hae Young

AU - Kim, Hyung Sik

AU - Jung, Jee H.

PY - 2012/12/28

Y1 - 2012/12/28

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AB - Seven new amino acid derivatives (1-4 and 6-8) were isolated from MeOH extracts of the marine ascidian Herdmania momus. Planar structures were established on the basis of NMR, IR, and MS spectroscopic analyses. Absolute configurations of these compounds were derived from specific rotation and CD analysis. The peroxisome proliferator-activated receptor (PPAR)-γ agonistic activities of the compounds were investigated due to the similarity of the structural motif to that of the antidiabetic drug rosiglitazone. Analogues with indoleglyoxyl moieties (5, 6, and 8) showed significant PPAR-γ activation in Ac2F rat liver cells.

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PPAR-γ agonistic metabolites from the ascidian Herdmania momus

Abstract

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