Prokaryotic 2-component systems and the ompr/phob superfamily

Minh Phuong Nguyen, Joo Mi Yoon, Man Ho Cho, Sang Won Lee

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

In bacteria, 2-component regulatory systems (TCSs) are the critical information-processing pathways that link stimuli to specific adaptive responses. Signals perceived by membrane sensors, which are generally histidine kinases, are transmitted by response regulators (RRs) to allow cells to cope rapidly and effectively with environmental challenges. Over the past few decades, genes encoding components of TCSs and their responsive proteins have been identified, crystal structures have been described, and signaling mechanisms have been elucidated. Here, we review recent findings and interesting breakthroughs in bacterial TCS research. Furthermore, we discuss structural features, mechanisms of activation and regulation, and cross-regulation of RRs, with a focus on the largest RR family, OmpR/PhoB, to provide a comprehensive overview of these critically important signaling molecules.

Original languageEnglish
Pages (from-to)799-810
Number of pages12
JournalCanadian Journal of Microbiology
Volume61
Issue number11
DOIs
Publication statusPublished - 22 Jul 2015

Bibliographical note

Publisher Copyright:
© 2015, National Research Council of Canada. All Rights Reserved.

Keywords

  • 2-component system
  • Bacterial signal transduction
  • OmpR/PhoB family. M.-P
  • Response regulator

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