Protective effect of Puerariae Radix on ovariectomy-induced bone loss in rats

Jeong A. Park; Sung Ok Lee; Eunjung Moon; May Kim; Seong Cheol Lim; Min Hyoung Cho; Sun Yeou Kim

Protective effect of Puerariae Radix on ovariectomy-induced bone loss in rats

Jeong A. Park
, Sung Ok Lee
, Eunjung Moon
, May Kim
, Seong Cheol Lim
, Min Hyoung Cho
, Sun Yeou Kim

Research output: Contribution to journal › Article › peer-review

Abstract

To examine the bone-protective effects of Puerariae Radix (PR) in an estrogen-deficient animal model, we treated ovariectomized rats with PR at a dose of 10.0 mg/kg 3 times a week for 16 weeks. Our results showed that PR increased mineral content and density of the trabecular bone at the neck of the left femur. Moreover, biochemical data indicated that PR had a positive effect on bone turnover. No endometrial hyperplasia was detected in the PR group. The present data suggest that PR should be considered for use in the treatment of bone loss in women with postmenopausal osteoporosis.

Original language	English
Pages (from-to)	189-197
Number of pages	9
Journal	Natural Product Sciences
Volume	17
Issue number	3
Publication status	Published - 2011

Keywords

Bone-protective effect
Osteoporosis
Puerariae Radix

Cite this

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title = "Protective effect of Puerariae Radix on ovariectomy-induced bone loss in rats",

abstract = "To examine the bone-protective effects of Puerariae Radix (PR) in an estrogen-deficient animal model, we treated ovariectomized rats with PR at a dose of 10.0 mg/kg 3 times a week for 16 weeks. Our results showed that PR increased mineral content and density of the trabecular bone at the neck of the left femur. Moreover, biochemical data indicated that PR had a positive effect on bone turnover. No endometrial hyperplasia was detected in the PR group. The present data suggest that PR should be considered for use in the treatment of bone loss in women with postmenopausal osteoporosis.",

keywords = "Bone-protective effect, Osteoporosis, Puerariae Radix",

author = "Park, \{Jeong A.\} and Lee, \{Sung Ok\} and Eunjung Moon and May Kim and Lim, \{Seong Cheol\} and Cho, \{Min Hyoung\} and Kim, \{Sun Yeou\}",

year = "2011",

language = "English",

volume = "17",

pages = "189--197",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

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TY - JOUR

T1 - Protective effect of Puerariae Radix on ovariectomy-induced bone loss in rats

AU - Park, Jeong A.

AU - Lee, Sung Ok

AU - Moon, Eunjung

AU - Kim, May

AU - Lim, Seong Cheol

AU - Cho, Min Hyoung

AU - Kim, Sun Yeou

PY - 2011

Y1 - 2011

N2 - To examine the bone-protective effects of Puerariae Radix (PR) in an estrogen-deficient animal model, we treated ovariectomized rats with PR at a dose of 10.0 mg/kg 3 times a week for 16 weeks. Our results showed that PR increased mineral content and density of the trabecular bone at the neck of the left femur. Moreover, biochemical data indicated that PR had a positive effect on bone turnover. No endometrial hyperplasia was detected in the PR group. The present data suggest that PR should be considered for use in the treatment of bone loss in women with postmenopausal osteoporosis.

AB - To examine the bone-protective effects of Puerariae Radix (PR) in an estrogen-deficient animal model, we treated ovariectomized rats with PR at a dose of 10.0 mg/kg 3 times a week for 16 weeks. Our results showed that PR increased mineral content and density of the trabecular bone at the neck of the left femur. Moreover, biochemical data indicated that PR had a positive effect on bone turnover. No endometrial hyperplasia was detected in the PR group. The present data suggest that PR should be considered for use in the treatment of bone loss in women with postmenopausal osteoporosis.

KW - Bone-protective effect

KW - Osteoporosis

KW - Puerariae Radix

UR - https://www.scopus.com/pages/publications/82355171664

M3 - Article

AN - SCOPUS:82355171664

SN - 1226-3907

VL - 17

SP - 189

EP - 197

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 3

ER -

Protective effect of Puerariae Radix on ovariectomy-induced bone loss in rats

Abstract

Keywords

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