Protective immunity induced by virus-like particle containing merozoite surface protein 9 of plasmodium berghei

Su Hwa Lee, Hae Ji Kang, Ki Back Chu, Swarnendu Basak, Dong Hun Lee, Eun Kyung Moon, Fu Shi Quan

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Merozoite surface protein 9 (MSP-9) from Plasmodium has shown promise as a vaccine candidate due to its location and possible role in erythrocyte invasion. In this study, we generated virus-like particles (VLPs) targeting P. berghei MSP-9, and investigated the protection against lethal doses of P. berghei in a mouse model. We found that VLP vaccination induced a P. berghei-specific IgG antibody response in the sera and CD4+ and CD8+ T cell populations in blood compared to a naïve control group. Upon challenge infection with P. berghei, vaccinated mice showed a significant increase in CD4+ and CD8+ effector memory T cell and memory B cell populations. Importantly, MSP-9 VLP immunization inhibited levels of the pro-inflammatory cytokines IFN-γ and IL-6 in the spleen and parasite replication in blood, resulting in significantly prolonged survival time. These results suggest that the MSP-9 VLP vaccine may constitute an effective malaria vaccine.

Original languageEnglish
Article number428
Pages (from-to)1-12
Number of pages12
JournalVaccines
Volume8
Issue number3
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Merozoite surface protein 9
  • Plasmodium berghei
  • Vaccine
  • Virus-like particle

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