Rapid, specific, and ultrasensitive fluorogenic sensing of phosgene through an enhanced PeT mechanism

Tae Il Kim, Dami Kim, Jean Bouffard, Youngmi Kim

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

We report the design of an enhanced PeT-based fluorogenic phosgene probe 1-CN comprising a BODIPY fluorescence reporter, and a catechol quencher at the meso-position acting as the phosgene reaction site. The fluorescent catechol-derived probe 1-CN specifically reacts with phosgene to result in a cyclic carbonate ester. The fast (< 3 s) reaction suppresses a reductive PeT quenching process, leading to a fluorescence turn-on signal (F/F0 up to ca. 1300). The high sensitivity (LOD = 24 pM) of the probe is achieved by the precise adjustment of the energy levels of the frontier orbitals involved in the PeT.

Original languageEnglish
Pages (from-to)458-462
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume283
DOIs
Publication statusPublished - 15 Mar 2019

Keywords

  • BODIPY
  • Fluorescent turn-on probe
  • Phosgene
  • Photoinduced electron transfer (PeT)
  • Sensing

Fingerprint

Dive into the research topics of 'Rapid, specific, and ultrasensitive fluorogenic sensing of phosgene through an enhanced PeT mechanism'. Together they form a unique fingerprint.

Cite this